Effects of aging on hard tissue formation using Low-intensity pulsed ultrasound and BMP

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462883
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: YAMAJI KOZO 岡山大学, 大学病院, 講師 (30374531)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 低出力超音波パルス / BMP / 硬組織形成 / 加齢

Outline of Final Research Achievements

This study evaluated the effects of aging on hard tissue formation induced by BMP using Low-intensity pulsed ultrasound（LIPUS）in young and aged rats.
Tertialy dentin formation was promoted by using pulp capping material contained BMP when LIPUS treatment was performed. There was no significant difference between the young and the aged rat in the volume of tertialy dentin. Newly formed bone was promoted by implantation of material contained BMP at palatal subperiosteal site when LIPUS treatment was performed, although the volume of bone decreased with aging. These results suggest that the effects of aging on hard tissue formation might vary with the experimental sites.

Free Research Field

歯科保存学