The effect of glycative stress on functions and signal transduction networks in skeletal muscle

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560371
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Toyohashi Sozo University
• Principal Investigator: EGAWA Tatsuro 豊橋創造大学, 健康科学研究科, 協力研究員 (00722331)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖化 / AGEs / 骨格筋 / リン酸化 / タンパク質合成 / タンパク質分解 / 筋形成 / 筋成長

Outline of Final Research Achievements

The purpose of this study was to investigate the effect of glycative stress on skeletal muscle functions. The treatment of advanced glycation end products (AGEs) in C2C12 skeletal muscle cells affected phosphorylated state of proteins associated with glucose metabolism and/or muscle development. In addition, the consumption of diets containing high AGEs suppressed skeletal muscle growth via inhibiting muscle development and protein synthesis in mice. These data suggest that glycative stress deteriorates skeletal muscle functions.

Free Research Field

骨格筋生化学