2015 Fiscal Year Final Research Report
Development of label-free and quantitative imaging of cell adhesion
| Project/Area Number |
26650046
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Saitama University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAZAKI Gen 北海道大学, 低温科学研究所, 教授 (60261509)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 光イメージング法 / 細胞接着 / 光干渉 / 原子間力顕微鏡 / 細胞培養基板設計 / がん細胞 / 定量計測 |
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| Outline of Final Research Achievements |
In this work, a high-contrast and quantitative imaging method of cell adhesion has been developed by improving instruments and analysis of optical interferometry. In addition, the new method was applied to the study of the quantitative correlation between adhesion and functions of various cells. In particular, the method provided the first quantitative insights into the correlation between adhesion and metastatic ability of cancer cells, which clearly shows the potential of this method for the applications to label-free screening of cell adhesion.
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| Free Research Field |
生物物理化学
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