Development of simple and noninvasive method to assess the severity of heart failure

2014 Fiscal Year Final Research Report

• Project/Area Number: 26670402
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Osaka University
• Principal Investigator: TAKASHIMA Seiji 大阪大学, 生命機能研究科, 教授 (90379272)
• Co-Investigator(Kenkyū-buntansha): ASANO Yoshgihiro 大阪大学, 医学系研究科 (60527670)
• Co-Investigator(Renkei-kenkyūsha): TSUKAMOTO Osamu 大阪大学, 医学系研究科 (80589151) ; HIGO Shuichiro 大阪大学, 医学系研究科 (00604034)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: 心不全 / 利尿ホルモン / モデル動物

Outline of Final Research Achievements

Natriuretic peptides (ANP and BNP) are physiologically active substances secreted from the heart during heart failure. Their diuretic function works on the improvement of heart failure. Both ANP and BNP have already been frequently used in clinical heart failure as therapeutic agents. In this study we revealed a mechanism for adjusting the expression of natriuretic peptides in failing heart. At the same time, we developed a technique for quantifying severity of heart failure by utilizing this phenomenon. Establishment of the pathogenesis and treatment of heart failure is expected by the study in the future.

Free Research Field

循環器内科