Novel antioxidant therapy for radiation-induced injuries

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670569
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Defense Medical College
• Principal Investigator: Kinoshita Manabu 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 免疫・微生物学, 准教授 (70531391)
• Co-Investigator(Renkei-kenkyūsha): Maruyama Toru 熊本大学, 薬学部, 教授 (90423657)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 放射線防護剤 / ビタミンC / 糖転移ビタミンC / 抗酸化アルブミン / 糖転移へスぺリジン / 放射線治療

Outline of Final Research Achievements

We studied vitamin C as a radioprotective agent, focusing on its antioxidative effect. We examined the effect of post-exposure treatment with intraperitoneal administration of vitamin C on radiation-induced bone marrow dysfunction in mice. Administration with high-dose vitamin C, even at 24 h after whole-body irradiation, was still effective in avoiding bone marrow dysfunction, thereby increasing mouse survival after radiation. Ascorbic acid 2-glucoside (AA2G) is a stabilized derivative of vitamin C and rapidly hydrolysed into vitamin C and glucose in the hosts. We examined the effect of AA2G treatment during pelvic radiotherapy against bladder tumors in tumor-bearing rats. AA2G treatment during the pelvic radiotherapy improved radiation-induced intestinal damage without reducing antitumor effect of pelvic radiotherapy. Vitamin C as well as AA2G may be useful for patients receiving not only accidental radiation exposure but also scheduled radiotherapy against neoplasms.

Free Research Field

放射線防護学