Analysis of macrophages in Adult onset Still's disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 26713036
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Yokohama City University
• Principal Investigator: KIRINO Yohei 横浜市立大学, 医学部, 講師 (50468154)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ベーチェット病 / マクロファージ / ERAP1 / CCR1 / IL-10 / ゲノムワイド関連解析

Outline of Final Research Achievements

In the current study, we have evaluated the ERAP1 allotype in Turkish population. We identified 10 distinct ERAP1 allotypes. Among them, only hap10 conferred strong risk for BD. Hap 10 and HLA-B51 showed significant gene-gene interaction. Expression analysis of CCR1 and IL10 showed high expression of these molecules in M2 macrophages. Skin regions of BD patients showed M1-macrophage predominant inflammation. These results show promise for targeting GWAS-identified genes for treatment strategy for BD.

Free Research Field

リウマチ・膠原病