Identification and charecterization of TICAM-1-signalosome components

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860033
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: Funami Kenji 北海道大学, 医学(系)研究科(研究院), 博士研究員 (00421983)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: TICAM-1 / TLR3 / 自然免疫 / インターフェロン

Outline of Final Research Achievements

TLR3 recognizes double-stranded RNA and mediate innate immune response. TICAM-1 acts as adaptor molecule for TLR3-mediated downstream signaling. In this study, we searched components of TICAM-1-signalosome, which is a protein complex acted as scaffold for TICAM-1-mediated innate immune signal transduction. Some proteins was identified as TICAM-1-signalosome components. From these, 14-3-3-zeta, a cytosolic proteins, was indispensable for TICAM-1-mediated inflammatory cytokine production and type I interferon production. Furthermore, 14-3-3-zeta is associated with TICAM-1-signalosome formation. These result suggested that 14-3-3-zeta is a novel component in TICAM-1-signalosome.

Free Research Field

免疫生物学