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2015 Fiscal Year Final Research Report

Ultrastructural abnormalities in nonalcoholic steatohepatitis

Research Project

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Project/Area Number 26860465
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Legal medicine
Research InstitutionKyoto University

Principal Investigator

Miyao Masashi  京都大学, 医学(系)研究科(研究院), 助教 (90711466)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywords法医病理学
Outline of Final Research Achievements

We aimed to elucidate the precise role of Liver sinusoidal endothelial cell (LSEC) in the pathophysiology of NAFLD using two different mouse models. LSEC injury appeared during the simple steatosis phase, and preceded the appearance of activated Kupffer cells and hepatic stellate cells (HSCs). These results indicate that LSEC injury may have a ‘gatekeeper’ role in the progression from simple steatosis to the early nonalcoholic steatohepatitis (NASH) stage, and LSEC injury may be necessary for the activation of Kupffer cells and HSCs, which in turn results in the development and perpetuation of chronic liver injuries.

Free Research Field

法医学

URL: 

Published: 2017-05-10  

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