2016 Fiscal Year Final Research Report
The effect of SCRN1 on neuronal differentiation
| Project/Area Number |
26860853
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
tezuka yu 岩手医科大学, 薬学部, 助教 (70453321)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 神経分化 / 発生 |
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| Outline of Final Research Achievements |
Secernin (SCRN)1 whose expression is detected in various tissues has been known to enhance the growth of many types of cells including cancer cells. In this study, our results suggest that change in SCRN1 expression can influence neuronal differentiation such as nurite outgrowth in neuronal cells. It was revealed that the fetal development is inhibited by decreased in expression of SCRN1 in SCRN1 gene trap mice. Since the expression level of SCRN1 is reduced in chick cerebellum under hypothyroid condition during fetal development, the results in this study are useful information to address new therapeutic approches of hypothyroid diseases.
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| Free Research Field |
薬理学
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