The effect of colforsin daropate on cardiac function during respiratory acidosis.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861516
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Hokkaido University
• Principal Investigator: Itami Takaharu 北海道大学, 獣医学研究科, 特任助教 (90724203)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アシドーシス / コルホルシンダロパート / 心拍出量 / ドブタミン / 肺動脈圧

Outline of Final Research Achievements

Acidosis is known to attenuate catecholamine reactivity and decrease cardiac contractility. Colforsin daropate effects on cardiac contractility and vasodilation by directly activating adenylate cyclase without mediation of catecholamine β1 receptor. In this study, we investigated the effect of colforsin on cardiovascular function during acidosis.
Six beagle dogs were administered colforsin and dobutamine which is a catecholamine alternately at normal and respiratory acidosis conditions. Cardiac output and heart rate were increased and systemic vascular resistance was decreased in both drugs in dose-dependent manner, and their effects were suppressed during acidosis condition as compared with normal condition. Pulmonary artery pressure was increased with dobutamine but not with colforsin.

Free Research Field

麻酔・集中治療