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1989 Fiscal Year Final Research Report Summary

Antitumor activity of monocyte-macrophages and its potentiation in cancer patients

Research Project

Project/Area Number 63570293
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionTokushima University School of Medicine

Principal Investigator

SONE Saburo  Tokushima Univ. Sch. of Med., Lecturer, 医学部・附属病院, 講師 (40145024)

Co-Investigator(Kenkyū-buntansha) OKUBO Akio  Tokushima University School of Medicine Assistant internist, 医学部・附属病院, 助手 (90203728)
Project Period (FY) 1988 – 1989
KeywordsMonocyte / Alveolar macrophage / Monokine / Interleukin 1 / Lung cancer / tumor necrosis factor
Research Abstract

The present studies were performed to elucidate the mechaniss by which human activated mosocyte-macrophages kill tumor cells. Membrane-associated interieukin 1alpha (IL-1alpha ) induced by synergistic actions of IFN-gamma and synthetic adjutant, was found to be a mediator of human monodyte-mediated tumor cell killing. Human alveolar macrophages and monocyte-derived macrophages had abilities to produce cell-associated IL-1alpa activity and tamior necrosis factor (TNF) more than blood sonocytes. We also found that human monocyte-mediated cytotoxicity against human selanona (A375) cells was mediated in part by a new tumor cytotoxic factor (KW, 30,000; PI 6), differing from IL-1 and TMF-alpha. Abilities of blood monocytes of lung cancer patients to express antitamor activity and to produce IL-1 were analyzed. The presence of lung cancer significantly increased the number of barvested blood monocytes. Spontaneous tumoricidel activity of these monocutes was slightly high as compared to those of healthy donors. Nevertheless, there was no difference in production of IL-1 between two groups. Blood monocutes of lung cancer patients were less cytotaxic than healthy donors subsequent to incubation with synthetic immunoadjuvant, but were as tomoricidal as those from healthy donors when activated with liposome-entrapped immunoadjuvant. Human II-2-activated killer cells were cytotoxic to alveolar macrophages and to macrophates matured by GM-CSF from blood sonocytes. These observations suggest that alveolar macrophages may play a critical role in situ regulation of pulmonary inflammatory and immune reactions through production of cell- associated IL-1alpha and INF.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Okubo, A. et al.: "Membrane-associated interleukin 1 as a mediator of tumor cell killing by human blood monocytes fixed with paraformaldehyde" Cancer Research. 49. 265-270 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura, S., et al.: "Antitumor potential of pleural cavity macrophages in lung cancer patients without malignant effusion" British Journal of Cancer 59:535-539, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Singh, S.M., et al.: "Up-regulation by granulocyte-macrophage colony stimulating factor of induction of lymphokine-activated killer (LAK) cells by human blood monocytes" International Journal of Cancer 44:662-669, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inamura, N., et al.: "Tumor cytotoxicity of human monocyte membrane-IL-1 induced by synergistic actions of interferon r and synthetic acyltripeptide, FK-562" Cancer Immunology Immunotherapy 28:164-170, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sone, S., et al.: "Killing of alveolar macrophages and of monocytes that have responded to granulocyte-macrophage colony stimulating factor by human lymphokine-activated killer cells" Japanese Journal of Cancer Research, 80:662-669, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sone, S., et al.: "Normal human alveolar macrohages have more ability than blood monocytes to produce cell-associated interleukin 1" American Journal of Respiratory Cell and Molecular Biology, 1:507-515, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sone, S., et al.: "Synergism of synthetic acyltripeptide and its analogs with recombinant interferon r for activation of antitumor properties of human blood monocytes" Cancer Immunology Immunotherapy 27:33-37, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sone, S., et al.: "Activation of human monocyte-macrophages to the tumoricidal state by liposomal macropahge activators" Gann Monograph on Cancer Research 34:121-130, 1988.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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