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Basic Research on Congenital Disorders of Glycosylation (CDG)

Research Project

Project/Area Number 19390093
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionResearch Institute, Osaka Medical Center for Maternal and Child Health

Principal Investigator

WADA Yoshinao  Research Institute, Osaka Medical Center for Maternal and Child Health, 研究所長 (00250340)

Co-Investigator(Kenkyū-buntansha) SHIBUKAWA Yukinao  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 代謝部門, 研究員 (90393264)
TAJIRI Michiko  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 代謝部門, 流動研究員 (70581312)
DAIMON Etsuko  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 代謝部門, 研究技術員 (90581314)
OKAMOTO Nobuhiko  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター, 遺伝診療科, 科長 (30416242)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords糖鎖 / 生合成 / 代謝異常症 / 質量分析 / 糖タンパク質 / 精神運動発達遅滞 / プロテオーム / 分析科学 / 異常代謝学 / 糖鎖合成異常症 / ムチン型糖鎖 / フコース
Research Abstract

Congenital Disorders of Glycosylation (CDG) is a large group of diseases caused by defects in glycan biosysthesis of glycoproteins. To obtain our knowledge of CDG that would be present in undiagnosed patients with developmental delay, methods for molecular diagnosis have been developed and introduced to clinical practice. Finally we found seven patients among 700 examined. The result tells us considerably high frequency of CDG. In addition, some technological developments for glycan analysis have been made.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (111 results)

All 2010 2009 2008 2007 Other

All Journal Article (41 results) (of which Peer Reviewed: 13 results) Presentation (39 results) Book (13 results) Remarks (2 results) Patent(Industrial Property Rights) (16 results) (of which Overseas: 1 results)

  • [Journal Article] Quantitation of saccharide compositions of O-glycans by mass spectrometry of glycopeptides and its application to rheumatoid arthritis.2010

    • Author(s)
      Wada Y, Tajiri M, Ohshima S.
    • Journal Title

      J Proteome Res 9

      Pages: 1367-1373

    • Related Report
      2010 Final Research Report
  • [Journal Article] Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1.2010

    • Author(s)
      Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Backstrom M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Hayes CE, Kato K, Kawasaki N, Khoo KH, Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Palaima E, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N.
    • Journal Title

      Mol Cell Proteomics 9

      Pages: 719-727

    • Related Report
      2010 Final Research Report
  • [Journal Article] High-energy electron transfer dissociation (HE-ETD) using alkali metal targets for sequence analysis of post-translational peptides.2010

    • Author(s)
      Hayakawa S, Matsumoto S, Hashimoto M, Iwamoto K, Nagao H, Toyoda M, Shigeri Y, Tajiri M, Wada Y.
    • Journal Title

      J Am Soc Mass Spectrom 21

      Pages: 1482-1489

    • Related Report
      2010 Final Research Report
  • [Journal Article] Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion.2010

    • Author(s)
      Shibukawa Y, Yamazaki N, Kumasawa K, Daimon E, Tajiri M, Okada Y, Ikawa M, Wada Y.
    • Journal Title

      Mol Biol Cell 21

      Pages: 3973-3984

    • Related Report
      2010 Final Research Report
  • [Journal Article] Brain endothelial cells produce amyloid β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form.2010

    • Author(s)
      Kitazume S, Tachida Y, Kato M, Yamaguchi Y, Honda T, Hashimoto Y, Wada Y, Saito T, Iwata N, Saido T, Taniguchi N.
    • Journal Title

      J Biol Chem 285

      Pages: 40097-40103

    • Related Report
      2010 Final Research Report
  • [Journal Article] Quantitation of saccharide compositions of O-glycans by mass spectrometry of glycopeptides and its application to rheumatoid arthritis.2010

    • Author(s)
      Wada Y, Tajiri M, Ohshima S.
    • Journal Title

      J Proteome Res

      Volume: 9 Pages: 1367-1373

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of methods for profiling O-glycosylation : Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1.2010

    • Author(s)
      Wada Y, et al.
    • Journal Title

      Mol Cell Proteomics

      Volume: 9 Pages: 719-727

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-energy electron transfer dissociation (HE-ETD) using alkali metal targets for sequence analysis of post-translational peptides.2010

    • Author(s)
      Hayakawa S, et al.
    • Journal Title

      J Am Soc Mass Spectrom

      Volume: 21 Pages: 1482-1489

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion.2010

    • Author(s)
      Shibukawa Y, et al.
    • Journal Title

      Mol Biol Cell

      Volume: 21 Pages: 3973-3984

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain endothelial cells produce amyloid β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form.2010

    • Author(s)
      Kitazume S, et al.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 40097-40103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitation of saccharide compositions of O-glycans by mass spectrometry of glycopeptides and its application to rheumatoid arthritis2010

    • Author(s)
      Wada Y, Tajiri M, Chshima S.
    • Journal Title

      J Proteoms Res 9 (3)

      Pages: 1367-1373

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Comparison of methods for profiling O-glycosylation : HUPO Human Disease Glycmics/Proteome Initiative multi-institutional study of IgA12010

    • Author(s)
      Wada Y, Dell A
    • Journal Title

      Mol Call Proteomics 9 (4)

      Pages: 719-727

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Dissociation profile of protonated fucosyl glycopeptides and quantitation of fucosylation levels of glycoproteins by mass spectrometry.2009

    • Author(s)
      Tajiri M, Kadoya M, Wada Y.
    • Journal Title

      J Proteome Res 8

      Pages: 688-693

    • Related Report
      2010 Final Research Report
  • [Journal Article] An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by β1,4-N-acetylglucosaminyltransferase III.2009

    • Author(s)
      Sato Y, Isaji T, Tajiri M, Yoshida-Yamamoto S, Yoshinaka T, Somehara T, Fukuda T, Wada Y, Gu J.
    • Journal Title

      J Biol Chem 284

      Pages: 11873-11881

    • Related Report
      2010 Final Research Report
  • [Journal Article] Distinct features of matrix-assisted 6μm infrared laser desorption/ionization mass spectrometry in biomolecular analysis.2009

    • Author(s)
      Tajiri M, Takeuchi T, Wada Y.
    • Journal Title

      Anal Chem 81

      Pages: 6750-6755

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dissociation profile of protonated fucosyl glycopeptides and quantitation of fucosyl ation levels of glycoproteins by mass spectrometry2009

    • Author(s)
      Tajiri M. Kadoya M, Wada Y.
    • Journal Title

      J Proteome Res 8 (2)

      Pages: 688-693

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] J Biol Chem An N-glycosylation site on the β-propeller domain of the integrin α 5 subunit plays key roles in both its function and site-specific modification by β12009

    • Author(s)
      Sato Y, Isaji T
    • Journal Title

      4-N-acetylglucosaminyltransferase III 284 (18)

      Pages: 11873-11881

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Distinct features of matrix-assisted6μ minfrared laser desorption/ionization mass spectrometry in biomol ecular analysis2009

    • Author(s)
      Tajiri M, Takeuchi T, Wada Y.
    • Journal Title

      Anal Chem 81 (16)

      Pages: 6750-6755

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Distinct features of matrix-assisted 6 μm infrared laser desorption/ionization mass snectrometry in biomolecular analysis2009

    • Author(s)
      Tajiri M
    • Journal Title

      Analytical Chemistry 81

      Pages: 6750-6755

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An N-glycosylation site on the β-propeller domain of the integrin a5 subunit plays key roles in both its function and site-specific modification by β1, 4-N-acetylglucosaminyltransferase III2009

    • Author(s)
      Sato Y
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 11873-11881

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissociation profile of protonated fucosyl glycopeptides and quantitation of fucosvlation levels of glycoproteins by mass spectrometry2009

    • Author(s)
      Tajiri M
    • Journal Title

      Journal of Proteome Research 8

      Pages: 688-693

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Wada Y.
    • Journal Title

      "Detection and characterization of protein mutations by mass spectrometry" in "The Protein Protocols Handbook 3rd Ed"(Humana Press)

      Pages: 1081-1094

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Oligosaccharide profiles of the prostate specific antigen in free and complexed forms from the prostate cancer patient serum and in seminal plasma : a glycopeptide approach.2008

    • Author(s)
      Tajiri M, Ohyama C, Wada Y.
    • Journal Title

      Glycobiology 18

      Pages: 2-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] N-Glycosylation of laminin-332 regulates its biological functions. A novel function of the bisecting GlcNAc.2008

    • Author(s)
      Kariya Y, Kato R, Itoh S, Fukuda T, Shibukawa Y, Sanzen N, Sekiguchi K, Wada Y, Kawasaki N, Gu J.
    • Journal Title

      J Biol Chem 283

      Pages: 33036-33045

    • NAID

      120006585494

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of reversed heme orientation on circular dichroism and cooperative oxygen binding of human adult hemoglobin.2008

    • Author(s)
      Nagai M, Nagai Y, Aki Y, Imai K, Wada Y, Nagatomo S, Yamamoto Y.
    • Journal Title

      Biochemistry 47

      Pages: 517-525

    • Related Report
      2010 Final Research Report
  • [Journal Article] Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer : a novel approach for the development of tumor markers.2008

    • Author(s)
      Nakano M, Nakagawa T, Ito T, Kitada T, Hijioka T, Kasahara A, Tajiri M, Wada Y, Taniguchi N, Miyoshi E.
    • Journal Title

      Int J Cancer 122

      Pages: 2301-2309

    • NAID

      130006997964

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oligosaccharide profiles of the prostate specific antigen in free and compl exed forms from prostate cancer patient serum and in seminal plasma : a glycopepti deapproach2008

    • Author(s)
      Tajiri M, Chyama C, Wada Y.
    • Journal Title

      Glycobiology 18

      Pages: 2-8

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] N-Glycosylation of Iaminin-332 regulates its biological functions. A novel function of the bisecting GlcNAc2008

    • Author(s)
      Kariya Y, Kato R
    • Journal Title

      J Biol Chem 283

      Pages: 33036-33045

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Effect of reversed heme orientation on circul ar dichroism and cooper ative oxygen binding of human adult hemoglobin2008

    • Author(s)
      Nagai M, Nagai Y
    • Journal Title

      Biochemistry 47

      Pages: 517-525

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Site-specific analysis of N-glycans on haptogl obin in sera of patients with pancreatic cancer : A novel approach for the devel opment of tumor markers2008

    • Author(s)
      Nakano M, Nakagawa T
    • Journal Title

      Int J Cancer 122

      Pages: 2301-2309

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Tackling difficulties in the determination of O-glycosylation sites : approaches to mucin-type glycoproteins2008

    • Author(s)
      Wada Y, Tajiri M.
    • Journal Title

      Trends Glycosci. Glycotechnol. 20

      Pages: 69-80

    • NAID

      10024188677

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Dissociation profile of protonated fucosyl glycopeptides and quantitation of fucosylation levels of glycoproteins by mass spectrometry2008

    • Author(s)
      Tajiri M. Kadoya M, Wada Y.
    • Journal Title

      Journal of Proteome Research 8

      Pages: 688-693

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tackling difficulties in the determination of O-glycosypation sites : approaches to mucin-type glycoproteins2008

    • Author(s)
      Wada Y, Tajiri M.
    • Journal Title

      Trends in Glycoscience and Glycotechnology 20

      Pages: 69-80

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligosaccharide profiles of the prostate specific antigen in free and complexed forms from prostate cancer patient serum and in seminal plasma : a glycopeptide approach2008

    • Author(s)
      Tajiri M, Ohyama C, Wada Y.
    • Journal Title

      Glycobiology 18

      Pages: 2-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.2007

    • Author(s)
      Wada Y, Azadi P, Costello CE, Dell A, Dwek RA, Geyer H, Geyer R, Kakehi K, Karlsson NG, Kato K, Kawasaki N, Khoo KH, Kim S, Kondo A, Lattova E, Mechref Y, Miyoshi E, Nakamura K, Narimatsu H, Novotny MV, Packer NH, Perreault H, Peter-Katalinic J, Pohlentz G, Reinhold VN, Rudd PM, Suzuki A, Taniguchi N.
    • Journal Title

      Glycobiology 17

      Pages: 411-422

    • NAID

      130006997954

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mass spectrometry in the detection and diagnosis of congenital disorders of glycosylation.2007

    • Author(s)
      Wada Y.
    • Journal Title

      Eur J Mass Spectrom (Chichester, Eng) 13

      Pages: 101-103

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ordered porous alumina geometries and surface metals for surface-assisted laser desorption/ionization of biomolecules: possible mechanistic implications of metal surface melting.2007

    • Author(s)
      Wada Y, Yanagishita T, Masuda H.
    • Journal Title

      Anal Chem 79

      Pages: 9122-9127

    • Related Report
      2010 Final Research Report
  • [Journal Article] Comparison of the methods for profiling glycoprotein glycans HUPO Human Disease Glycomcs/Proteome Initiative multi-institutional study2007

    • Author(s)
      Wada Y, Azadi P
    • Journal Title

      Glycobiology 17

      Pages: 411-422

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Mass spectrometry in the detection and diagnosis of congenital disorders of glycosylation2007

    • Author(s)
      Wada Y.
    • Journal Title

      Eur. J Mass Spectrom 13

      Pages: 101-103

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Mass spectrometry in the detection and diagnosis of congenital disorders of glycosylation2007

    • Author(s)
      Wada Y.
    • Journal Title

      European Journal of Mass Spectrometry 13

      Pages: 101-103

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the methods for profiling glycoprotein glycans-HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study2007

    • Author(s)
      Wada Y., et. al.
    • Journal Title

      Glycobiology 17

      Pages: 411-422

    • NAID

      130006997954

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] グライコプロテオミクスの現状と糖鎖合成異常症の診断支援活動について2010

    • Author(s)
      和田芳直
    • Organizer
      神戸大学大学院医学研究科第2回臨床メタボロミクス研究会
    • Place of Presentation
      神戸
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Clinical glycoproteomics : A survey of Congenital Disorders of Glycosylation (CDG) in developmental delay patients2010

    • Author(s)
      Wada Y.
    • Organizer
      51st Annual Meeting of the Korean Society for Laboratory Medicine (KSLM)
    • Place of Presentation
      韓国ソウル
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先天性糖鎖合成異常症の分子診断プログラム(第3報)2010

    • Author(s)
      和田芳直、角谷真知子、岡本伸彦
    • Organizer
      第35回日本医用マススペクトル学会年会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 質量で診断する2010

    • Author(s)
      和田芳直
    • Organizer
      第1回日本質量分析学会北海道談話会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-07-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中赤外レーザーを用いる脱離イオン化の特性と酸性糖質およびSニトロソ化合物への応用2010

    • Author(s)
      田尻道子、竹内孝江、和田芳直
    • Organizer
      第58回質量分析総合討論会
    • Place of Presentation
      つくばシンポジウム
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 中赤外レーザーを用いる脱離イオン化の特性と酸性糖質およびSニトロソ化合物への応用2010

    • Author(s)
      田尻道子、竹内孝江、和田芳直
    • Organizer
      第58回質量分析総合討論会
    • Place of Presentation
      つくば
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] O型糖鎖をもつ糖ペプチドのマススペクトルからの構成糖定量法2010

    • Author(s)
      和田芳直、田尻道子、大島至郎
    • Organizer
      第58回質量分析総合討論会
    • Place of Presentation
      つくば
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Determination of site-occupancy and saccharide compositions of glycoprotein O-glycans by mass spectrometry : key contribution of electron transfer dissociation2009

    • Author(s)
      Y.Wada
    • Organizer
      7th Annual Uppsala Conference on Electron Capture and Transfer Dissociation 2009
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Year and Date
      2009-12-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] A new perspective of O-glycoprpteomics2009

    • Author(s)
      和田芳直
    • Organizer
      The 13th Beijing Conference and Exhibition on Instrumental Analysis (BCEIA2009)
    • Place of Presentation
      北京、基調講演
    • Year and Date
      2009-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] A new perspective of O-glycoprpteomics2009

    • Author(s)
      Y.Wada
    • Organizer
      The 13th Beijing Conference and Exhibition on Instrumental Analysis(BCEIA2009)
    • Place of Presentation
      北京国際会議場(中国)
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖鎖バイオマーカー解析のための糖鎖プロファイル定量化-IgGとIgAへの応用2009

    • Author(s)
      和田芳直、角谷真知子、田尻道子
    • Organizer
      第34回日本医用マススペクトル学会年会
    • Place of Presentation
      東大阪、シンポジウム
    • Year and Date
      2009-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖バイオマーカー解析のための糖鎖プロファイル定量化-IgGとIgAへの応用2009

    • Author(s)
      和田芳直
    • Organizer
      第34回日本医用マススペクトル学会年会
    • Place of Presentation
      近畿大学(大阪府)
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distinct softness of matrix-assisted 6μm infrared laser desorption/ionization mass spectrometry2009

    • Author(s)
      Tajiri M
    • Organizer
      第18回国際質量分析学会
    • Place of Presentation
      ブレーメン国際会議場(ドイツ)
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] ありふれたタンパクの疾患糖鎖マーカー2009

    • Author(s)
      和田芳直
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京、シンポジウム
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ありふれたタンパクの疾患糖鎖マーカー2009

    • Author(s)
      和田芳直
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      北里大学(東京都)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distinct features of matrix-assisted 6μm infrared laser desorption/ionization mass spectrometry2009

    • Author(s)
      Wada Y
    • Organizer
      第57回米国質量分析学会
    • Place of Presentation
      フィラデルフィア(米国)
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中赤外レーザーによる酸性糖鎖のソフトイオン化2009

    • Author(s)
      田尻道子
    • Organizer
      第57回質量分析総合討論会
    • Place of Presentation
      大阪国際交流センター(大阪府)
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Soft ionization and dissociation required for glycoproteomic studies.2009

    • Author(s)
      和田芳直
    • Organizer
      第22回オーストラリアニュージーランド質量分析学会ANZSMS
    • Place of Presentation
      シドニー、招待講演
    • Year and Date
      2009-01-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Soft ionization and dissociation required for glycoproteomic studies2009

    • Author(s)
      Wada Y
    • Organizer
      ANZSMS2009
    • Place of Presentation
      シドニー
    • Year and Date
      2009-01-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical glycoproteomics : from CDG to O-glycoproteomics.2008

    • Author(s)
      和田芳直
    • Organizer
      日台科学技術セミナー・シンポジウム(タンパク質翻訳後修飾)
    • Place of Presentation
      台北
    • Year and Date
      2008-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical glycoproteomics : from CDG to O-glycoproteomics2008

    • Author(s)
      Wada Y
    • Organizer
      日台科学技術セミナー・シンポジウム(タンパク質翻訳後修飾)
    • Place of Presentation
      台北
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 先天性糖鎖合成異常症の分子診断プログラム-第2報-2008

    • Author(s)
      和田芳直, 角谷真知子, 田尻道子, 岡本伸彦
    • Organizer
      日本医用マススペクトル学会第33回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Getting a real picture of molecules for the diagnosis by MS.2008

    • Author(s)
      和田芳直
    • Organizer
      2008韓国質量分析学会2008
    • Place of Presentation
      済州、韓国plenary lecture
    • Year and Date
      2008-08-26
    • Related Report
      2010 Final Research Report
  • [Presentation] O-グリコプロテオームと電子移動解離MS2008

    • Author(s)
      和田芳直
    • Organizer
      日本ヒトプロテオーム機構第6回大会
    • Place of Presentation
      吹田シンポジウム
    • Year and Date
      2008-07-29
    • Related Report
      2010 Final Research Report
  • [Presentation] O-グリコプロテオームと電子移動解離MS2008

    • Author(s)
      和田芳直
    • Organizer
      日本ヒトプロテオーム機構第6回大会シンポジウム
    • Place of Presentation
      吹田
    • Year and Date
      2008-07-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] The stability of N-glycans of protonated glycopeptide ions in gas phase2007

    • Author(s)
      Tajiri M, Wada Y.
    • Organizer
      Annual Conference of the Society for Glycobiology.
    • Place of Presentation
      米国、ボストン
    • Year and Date
      2007-11-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glyco-biomedical mass spectrometry2007

    • Author(s)
      和田芳直
    • Organizer
      The 9th Asian Conferenceon Analytical Sciences
    • Place of Presentation
      韓国済州、招待講演Keynote Lecture
    • Year and Date
      2007-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Glyco-biomedical mass spectrometry2007

    • Author(s)
      Wada Y
    • Organizer
      The 9th Asian Conference on Analytical Sciences
    • Place of Presentation
      済州島
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 先天性糖鎖合成異常症CDGの分子診断プログラム2007

    • Author(s)
      和田芳直、角谷真知子、岡本伸彦
    • Organizer
      第32回日本医用マススペクトル学会年会
    • Place of Presentation
      京都
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Nグリカン定量に関するHUPO HGPIパイロット研究2007

    • Author(s)
      和田芳直
    • Organizer
      日本ヒトプロテオーム機構第5回大会
    • Place of Presentation
      東京、シンポジウム
    • Year and Date
      2007-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] MS of glycopeptides for glycoproteomics.2007

    • Author(s)
      和田芳直
    • Organizer
      台湾質量分析学会2007
    • Place of Presentation
      台南、plenary lecture
    • Year and Date
      2007-06-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Theoretical study on fragmentation mechanism of positive and negativeions of oligosaccharides2007

    • Author(s)
      Takeuchi T, Tajiri M, Wada Y.
    • Organizer
      55th ASMS Conference on Mass Spectrometry
    • Place of Presentation
      Indianapolis, USA
    • Year and Date
      2007-06-05
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Theoretical study on fragmentation mechanism of positive and negativeions of oligosaccharides2007

    • Author(s)
      Takeuchi T, Tajiri M, Wada Y
    • Organizer
      55th ASMS Conference on Mass Spectrometry
    • Place of Presentation
      米国インディアナポリス
    • Year and Date
      2007-06-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dissociation of core1,6 and antenna 1,3 fucosylated isomers in the MS of glycopeptides2007

    • Author(s)
      Tajiri M, Wada Y
    • Organizer
      55th ASMS Conference on Mass Spectrometry
    • Place of Presentation
      米国インディアナポリス
    • Year and Date
      2007-06-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] HUPO多施設共同パイロット研究-MSによる糖鎖定量-2007

    • Author(s)
      和田芳直
    • Organizer
      第55回質量分析総合討論会2007
    • Place of Presentation
      広島、シンポジウム
    • Year and Date
      2007-05-18
    • Related Report
      2010 Final Research Report
  • [Presentation] HUPO多施設共同パイロット研究-MISによる糖鎖定量-2007

    • Author(s)
      和田芳直
    • Organizer
      第55回質量分析総合討論会
    • Place of Presentation
      広島
    • Year and Date
      2007-05-18
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] N型糖鎖付加ペプチドにおけるコアα1, 6-フコースとルイス型α1, 3-フコースの解離について2007

    • Author(s)
      田尻道子, 和田芳直
    • Organizer
      第55回質量分析総合討論会
    • Place of Presentation
      広島
    • Year and Date
      2007-05-16
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 糖ペプチド構造解析におけるMALDIとESIの比較2007

    • Author(s)
      田尻道子, 和田芳直
    • Organizer
      第55回質量分析総合討論会
    • Place of Presentation
      広島
    • Year and Date
      2007-05-16
    • Related Report
      2009 Self-evaluation Report 2007 Annual Research Report
  • [Presentation] N型糖鎖付加ペプチドにおけるコアα1,6-フコースとルイス型α1,3-フコースの解離について2007

    • Author(s)
      田尻道子、和田芳直
    • Organizer
      第55回質量分析総合討論会
    • Place of Presentation
      広島
    • Year and Date
      2007-05-16
    • Related Report
      2007 Annual Research Report
  • [Book] 創薬・タンパク質研究のためのプロテオミクス解析(グライコプロテオミクスによる疾患糖鎖マーカー探索)(実験医学別冊)2010

    • Author(s)
      和田芳直
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report
  • [Book] 実験医学別冊「創薬・タンパク質研究のためのプロテオミクス解析」2010

    • Author(s)
      和田芳直
    • Total Pages
      227
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] "Detection and characterization of protein mutations by mass spectrometry" in "The Protein Protocols Handbook 3rd Ed"(John M Walker (ed.))2009

    • Author(s)
      和田芳直
    • Publisher
      Humana Press
    • Related Report
      2010 Final Research Report
  • [Book] 先天性グリコシル化異常症(CDG症候群)小児の症候群(小児科診療2009増刊号)2009

    • Author(s)
      和田芳直
    • Total Pages
      366
    • Publisher
      診断と治療社、東京
    • Related Report
      2010 Final Research Report
  • [Book] The Protein Protocols Handbook 3rd Ed(John M Walker (ed.), Detection and characterization of protein mutations by mass spectrometry)2009

    • Author(s)
      Wada Y.
    • Publisher
      Humana Press
    • Related Report
      2009 Self-evaluation Report
  • [Book] Mass spectrometry of glycopeptides in Experimental glycoscience: Glycochemistry (eds. Taniguchi N et al.)2008

    • Author(s)
      和田芳直
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Molecular diagnosis of congenital disorders of glycosylation in Experimental glycoscience : Glycobiology (eds. Taniguchi N et al.)2008

    • Author(s)
      和田芳直
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Experimental glrcoscience(eds. Taniguchi N et al., Mass spectrometry of glycopeptides)2008

    • Author(s)
      Wada Y.
    • Publisher
      Springer
    • Related Report
      2009 Self-evaluation Report
  • [Book] Experimental glycoscience: Glycobiology(eds. Taniguchi N et al., Molecular diagnosis of congenital disorders of glycosylation)2008

    • Author(s)
      Wada Y.
    • Publisher
      Springer
    • Related Report
      2009 Self-evaluation Report
  • [Book] O-グリコプロテオームの解析戦略(細胞工学別冊「プロテオミクス・メタボロミクス-質量分析の基礎からバイオ医薬への応用」)2007

    • Author(s)
      和田芳直、田尻道子、久田美貴、伊藤喜之
    • Publisher
      秀潤社 東京
    • Related Report
      2010 Final Research Report
  • [Book] 生体分子の質量分析(実験化学講座20-1)2007

    • Author(s)
      和田芳直
    • Publisher
      丸善、東京
    • Related Report
      2010 Final Research Report
  • [Book] 実験化学講座(生体分子の質量分析)2007

    • Author(s)
      和田芳直
    • Publisher
      丸善
    • Related Report
      2009 Self-evaluation Report
  • [Book] O-グリコプロテオームの解析戦略.細胞工学別冊「プロテオミクス・メタボロミクス-質量分析の基礎からバイオ医薬への応用」2007

    • Author(s)
      和田芳直、田尻道子、久田美貴、伊藤喜之
    • Total Pages
      9
    • Publisher
      秀潤社
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.osaka-u.ac.jp/pub/inst-mch/MM/MM.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.mch.pref.osaka.jp/sub_about/news/hp_news_cdg.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] IgAヒンジ部O結合型糖鎖構造に基づく疾患の判定方法2010

    • Inventor(s)
      飯島英樹、井上隆弘、和田芳直、三善英知、新崎信一郎、辻井正彦、林 紀夫、猪阪善隆、岩谷博次
    • Industrial Property Rights Holder
      国立大学法人大阪大学、地方独立行政法人大阪府立病院機構
    • Filing Date
      2010-12-10
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 二次元イメージング装置および方法2010

    • Inventor(s)
      永井亨、森本巌、横山稔、柳瀬悦也、和田芳直、田尻道子
    • Industrial Property Rights Holder
      川崎重工業株式会社
    • Industrial Property Number
      2010-136413
    • Filing Date
      2010-06-15
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Patent(Industrial Property Rights)] 多糖類検査装置および多糖類検査方法2010

    • Inventor(s)
      永井亨、森本巌、横山稔、柳瀬悦也、和田芳直、田尻道子
    • Industrial Property Rights Holder
      川崎重工業株式会社
    • Industrial Property Number
      2010-136422
    • Filing Date
      2010-06-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 標識アミド化を用いたタンパク質又はペプチドの解析法2010

    • Inventor(s)
      田中耕一、関谷禎規、和田芳直
    • Industrial Property Rights Holder
      株式会社島津製作所、地方独立行政法人大阪府立病院機構
    • Filing Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 表面加工が施された試料保持面を有する試料ターゲットおよびその製造方法、並びに当該試料ターゲットを用いた質量分析装置2010

    • Inventor(s)
      奥野昌二、和田芳直、荒川隆一
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構、地方独立行政法人大阪府立病院機構
    • Acquisition Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 電気泳動ゲルおよびその利2010

    • Inventor(s)
      和田芳直
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構、地方独立行政法人大阪府立病院機構
    • Acquisition Date
      2010-02-26
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 多糖類検査装置および多糖類検査方法2010

    • Inventor(s)
      永井亨、森本巌、横山稔、柳瀬悦也、和田芳直、田尻道子
    • Industrial Property Rights Holder
      川崎重工業株式会社
    • Industrial Property Number
      2010-136413
    • Filing Date
      2010-06-15
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] IgAヒンジ部O結合型糖鎖構造に基づく疾患の判定方法2010

    • Inventor(s)
      飯島英樹、井上隆弘、和田芳直、三善英知、新崎信一郎、辻井正彦、林紀夫、猪阪善隆、岩谷博次
    • Industrial Property Rights Holder
      国立大学法人大阪大学、地方独立行政法人大阪府立病院機構
    • Filing Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 表面加工が施された試料保持面を有する試料ターゲットおよびその製造方法、並びに当該試料ターゲットを用いた質量分析装置2010

    • Inventor(s)
      奥野昌二、和田芳直、荒川隆一
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構、地方独立行政法人大阪府立病院機構
    • Filing Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 標識アミド化を用いたタンパク質又はペプチドの解析法2010

    • Inventor(s)
      田中耕一、関谷禎規、和田芳直
    • Industrial Property Rights Holder
      株式会社島津製作所、地方独立行政法人大阪府立病院機構
    • Filing Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] IgAヒンジ部O結合型糖鎖構造に基づく疾患の判定方法2009

    • Inventor(s)
      飯島英樹、井上隆弘、和田芳直、三善英知、新崎信一郎、辻井正彦、林 紀夫、猪阪善隆、岩谷博次
    • Industrial Property Rights Holder
      国立大学法人大阪大学、地方独立行政法人大阪府立病院機構
    • Industrial Property Number
      2009-281519
    • Filing Date
      2009-12-11
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 質量分析法に用いられる試料ターゲットおよびその製造方法、並びに当該試料ターゲットを用いた質量分析装置2009

    • Inventor(s)
      益田秀樹、柳下崇、和田芳直
    • Industrial Property Rights Holder
      神奈川科学技術アカデミー、大阪府立病院機構
    • Industrial Property Number
      2009-017027
    • Filing Date
      2009-01-28
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 糖タンパク質構造解析手法2009

    • Inventor(s)
      田中耕一、和田芳直、山崎雄三
    • Industrial Property Rights Holder
      株式会社島津製作所、地方独立行政法人大阪府立病院機構
    • Acquisition Date
      2009-12-18
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 質量分析法に用いられる試料ターゲットおよびその製造方法、並びに当該試料ターゲットを用いた質量分析装置2008

    • Inventor(s)
      益田秀樹、柳下崇、和田芳直
    • Industrial Property Rights Holder
      神奈川科学技術アカデミー、大阪府立病院機構
    • Industrial Property Number
      2008-078976
    • Filing Date
      2008-03-25
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞融合制御法、それに用いる遺伝子組換え用ベクターおよび細胞融合制御剤2007

    • Inventor(s)
      渋川幸直、和田芳直
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Industrial Property Number
      2007-301832
    • Filing Date
      2007-11-21
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞融合制御法、それに用いる遺伝子組み換え用ベクターおよび細胞融合制御剤2007

    • Inventor(s)
      渋川幸直、和田芳直
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Filing Date
      2007-11-21
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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