KAKEN — Research Projects | Researcher Number: 20131542

Search Results: 15 results / Researcher Number: 20131542

Display:

1. Elucidation of vitamin K side chain cleavage enzyme aiming at unified understanding of vitamin K synthesis mechanism

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Environmental and hygienic pharmacy
Research Institution	Shibaura Institute of Technology
Principal Investigator	HIROTA Yoshihisa 芝浦工業大学, システム理工学部, 助教
Project Period (FY)	2016-04-01 – 2018-03-31Completed
Keywords	ビタミンK / 側鎖切断酵素 / 2',3'-PKH2 / 代謝機構 / UBIAD1 / MK-4 / MD / 遺伝子改変 / 小腸 / オミクス解析 / 遺伝子改変動物 / 腸
Outline of Final Research Achievements	In humans and mice, ingested PK is MD which has a side chain cleaved in the small intestine and has no side chains and is converted into MK-4 by UBIAD ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 11 results, Open Access: 11 results, Acknowledgement Compliant: 3 results) Presentation (15 results, of which Invited: 1 results) Remarks (2 results)

2. Development of retinoic acid analog exhibiting a separeted function of the heterodimeric-nuclear receptors

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Drug development chemistry
Research Institution	Kobe Pharmaceutical University
Principal Investigator	WADA Akimori 神戸薬科大学, 薬学部, 教授
Project Period (FY)	2011 – 2013Completed
Keywords	9cis-レチノイン酸 / ヘテロダイマー / クロスカップリング / テルペン誘導体 / ビニルトリフラート / スズオレフィン / RXR / 9cis-レチノイン酸アナログ
Research Abstract	Retinoid X receptor (RXR) agonists are interesting candidates for the treatment of metabolic syndrome. 9-Cis-retinoic acid (9cRA) is a natural RXR ago ...

Research Products of this project	Journal Article (26 results, of which Peer Reviewed: 26 results) Presentation (48 results) Book (4 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results, of which Overseas: 1 results)

3. Generation and characterization of genetically-altered mice lacking a novel vitamin K2 synthesis enzyme Ubiad1

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Biological pharmacy
Research Institution	Kobe Pharmaceutical University
Principal Investigator	OKANO TOSHIO 神戸薬科大学, 薬学部, 教授
Project Period (FY)	2011-04-01 – 2014-03-31Completed
Keywords	遺伝子改変動物 / ビタミンK2 / 合成酵素 / UBIAD1 / 全身性ノック・アウト / コンデショナル・ノックアウト / 神経 / 骨 / ビタミンＫ2 / ＵＢＩＡＤ1 / 全身性ノックアウト / コンディショナル・ノックアウト / ヒト / 遺伝子欠損動物 / CAG-Creヘテロマウス / CAG-Flpヘテロマウス
Research Abstract	It was demonstrated that tissue vitamin K2 originates from oral vitamin K1 by a mechanism that involves the release of vitamin K3 from vitamin K1 in t ...

Research Products of this project	Journal Article (39 results, of which Peer Reviewed: 24 results) Presentation (98 results, of which Invited: 11 results) Book (13 results) Remarks (2 results)

4. Construction of an arteriosclerosis assessment system using genetically modified cells and animals, and drug development

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	Kobe Pharmaceutical University
Principal Investigator	OKANO Toshio Kobe Pharmaceutical University
Project Period (FY)	2008 – 2010Completed
Keywords	分子生物学 / 遺伝子改変細胞 / 遺伝子改変動物 / 動脈硬化モデル / ビタミンD / ビタミンK / 生合成酵素 / 活性評価 / 活性型ビタミンD / 受容体 / 活性化酵素
Research Abstract	To elucidate the role of vitamin D in the prevention and treatment of arteriosclerosis, we have generated vitamin D receptor(VDR) gene knockout mice o ...

Research Products of this project	Journal Article (44 results, of which Peer Reviewed: 38 results) Presentation (55 results) Book (13 results) Remarks (1 results)

5. Development of a fat soluble signal molecule for cancer chemotherapy

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Kobe Pharmaceutical University
Principal Investigator	WADA Akimori Kobe Pharmaceutical University
Project Period (FY)	2007 – 2009Completed
Keywords	癌 / シグナル伝達 / 核内受容体 / 生理活性 / イソプレノイド / 脂溶性リガンド
Research Abstract	As geranylgeranoic acid (GGA) was considered as an retinoic acid analog, various GGA analogs were efficiently synthesized and their biological activit ...

Research Products of this project	Journal Article (30 results, of which Peer Reviewed: 25 results) Presentation (54 results) Book (1 results) Remarks (3 results)

6. Construction of gene targeting animal models for evaluating preventive and therapeutic anti-cancer effectiveness of active vitamin D analogues

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	Kobe Pharmaceutical University
Principal Investigator	OKANO Toshio Kobe Pharmaceutical University, DEPARTMENT OF HYGIENIC SCIENCES, PROFESSOR
Project Period (FY)	2006 – 2007Completed
Keywords	VITAMIN D RECEPTOR / VITAMIND 1α HYDROXYLASE / GENE-TARGETING ANIMALS / METASTASIS OF CANCER CELLS / CANCER CELL GROWTH / GENE-TARGETING CELLS / CANCER CELL-INDUCED ANGIOGENESIS / NOVEL ACTIVE VITAMIN D ANALOGUES
Research Abstract	We have generated a line of animal model (1αOHase-/-) lacking the gene encoding vitamin D la-hydroxylase that is a key enzyme for activation of vitami ...

Research Products of this project	Journal Article (19 results, of which Peer Reviewed: 10 results) Presentation (15 results) Book (10 results)

7. Construction of evaluation system for vitamin D analogs

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Applied biochemistry
Research Institution	Toyama Prefectural University
Principal Investigator	SAKAKI Toshiyuki Toyama Prefectural Univ, Dept.Biotechnology, Professor
Project Period (FY)	2004 – 2005Completed
Keywords	vitamin D / cytochrome P450 / metabolism of vitamin D analog / CYP24A1 / CYP27B1 / site-directed mutagenesis / osteoporosis / cancer
Research Abstract	Mouse CYP27B1 was successfully overexpressed by using a GroEL/ES co-expression system. In a mutation study of mouse CYP27B1 that included spectroscopi ...

Research Products of this project	Journal Article (40 results)

8. Elucidation of the mechanism of cancer cell metastasis and permeation using active vitamin D as a molecular base and development of therapeutic agents

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	KOBE PHARMACEUTICAL UNIVERSITY
Principal Investigator	OKANO Toshio KOBE PHARMACEUTICAL UNIVERSITY, DEPARTMENT OF HYGIENIC SCIENCES, PROFESSOR
Project Period (FY)	2003 – 2005Completed
Keywords	ACTIVE VITAMIN D ANALOGS / VITAMIN D RECEPTOR / CHEMICAL STRUCTURE-ACTIVITY RELATIONSHIP / VITAMIN D METABOLISM / APOPTOSIS / CELL GROWTH AND DIFFERENTIATION / TUMOR INVASION AND METASTASIS / ANGIOGENESIS
Research Abstract	In the present study, we demonstrated from the in vitro and in vivo studies that 1α,25-dihydroxyvitamin D_3 (1α,25-D_3) and its derivatives are effect ...

Research Products of this project	Journal Article (40 results) Book (7 results) Publications (9 results)

9. DEVELOPMENT OF VITAMIN D ANALOGS POSSESSING STRUCTURAL SELECTIVE REGULATORY ACTIVITY TOWARDS CANCER CELL DIFFERENTIATION AND APOPTOSIS

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	KOBE PHARMACEUTICAL UNIVERSITY
Principal Investigator	OKANO Toshio KOBE PHARMACEUTICAL UNIVERSITY, DEPARTMENT OF HYGIENIC SCIENCES, PROFESSOR
Project Period (FY)	2000 – 2002Completed
Keywords	ACTIVE VITAMIN D ANALOGS / CANCER CELLS / STRUCTURE AND ACTIVITY / CELL DIFFERENTIATION - PROLIFERATION / GENE REGULATION / APOPTOSIS / CELL CYCLE / VITAMIN D RECEPTOR
Research Abstract	It has been well documented in vitro and in vivo that 1a, 25-dihydroxyvitamin D3 (1a, 25(OH)2D3), an active form of vitamin D3, exhibits a variety of ...

Research Products of this project	Publications (43 results)

10. がん治療を目的とした新規ビタミンD_3誘導体の開発研究

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section	Biological Sciences
Research Institution	Kobe Pharmaceutical University
Principal Investigator	津川尚子神戸薬科大学, 薬学部, 講師
Project Period (FY)	2000Completed
Keywords	活性型ビタミンD誘導体 / がん治療 / 構造と活性 / 細胞の分化・増殖 / 遺伝子転写調節 / アポトーシス / p21 / ビタミンD受容体
Research Abstract	がん治療への活性型ビタミンDの応用を目的として、1)分化誘導能能及びアポトーシス誘導能が高く、カルシウム作用の低い誘導体を得ること、2)誘導体による細胞分化、アポトーシス誘導の作用機序を解明すること、3)多種の誘導体のスクリーニングから、構造と活性の相関性を見いだし、今後の誘導体設計に役立てること、 ...

Research Products of this project	Publications (9 results)

11. Design of Synergistic Function and Dynamic Stereocontrol of Hetero multi-metal complexes

Research Project

Research Category	Grant-in-Aid for Scientific Research (B).
Research Field	Synthetic chemistry
Research Institution	Tokyo Institute of Technology
Principal Investigator	MIKAMI Koichi (1999-2001) Tokyo Inst. Tech., Fac. Eng., Prof. 寺田眞浩 (1998) 東京工業大学, 工学部, 助手
Project Period (FY)	1998 – 2000Completed
Keywords	Asymmetric activation / Dynamic stereocontrol / Hetero multi-metal complexes / Asymmetric catalysis / Vitamin D / Ene reaction / Vitamin D derivatives / Asymmetric synthesis / Biological activity / Differentiation
Research Abstract	While non-racemic catalysts can generate non-racemic products with or without the "non-linear relationship" in enantiomeric excesses between catalysts ...

Research Products of this project	Publications (36 results)

12. Structure-Activity Study of Vitamin D Analogues

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	Kobe Pharmaceutical University
Principal Investigator	OKANO Toshio Kobe Pharmaceutical University, Hygienic Sciences, Professor
Project Period (FY)	1997 – 1999Completed
Keywords	Active vitamin D analogues / Synthesis / Structure-Function / Cell differentiation and proliferation / Regulation of gene transcription / Apoptosis / Intracellular calcium / Osteoporosis
Research Abstract	To clarify the structure-function relationship of vitamin D analogues, we synthesized novel vitamin D analogues and evaluated their biological activit ...

Research Products of this project	Publications (56 results)

13. Nutritional and Biochemical Studiees on Vitamin D and Its Active Derivatives for Preventing Osteoporosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Biological pharmacy
Research Institution	Kobe Pharmaceutical University
Principal Investigator	KOBAYASHI Tadashi Kobe Pharmaceutical University Professor
Project Period (FY)	1994 – 1996Completed
Keywords	Active firm of vitamin D / Osteoporosis / Parathyroid hormone / Vitamin D receptor / Calcium / Bone formation / Bone resorption / Calcitonin
Research Abstract	We have investigated the nutritional and biochemical problems on vitamin D and its active derivatives and the following results have been obtained : ...

Research Products of this project	Publications (31 results)

14. Studies on the Physiological Activities of Novel Vitamin D_3 Derivatives

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	Kobe Women's College of Pharmacy
Principal Investigator	KOBAYASHI T Kobe Women's College of Pharmacy Professor
Project Period (FY)	1990 – 1992Completed
Keywords	Active Vitamin D_3 / Calcium / Osteporosis / Vitamin D Binding Protein / Differentiation / Immune Regulating Activity / Parathyroid / Receptor
Research Abstract	We have synthesized the two novel vitamin D_3 derivatives, 22-oxa-1,25-dihydroxyvitamin D_3 (oxacalcitriol : OCT) and 2beta-hydroxypropoxy-1,25-dihydr ...

Research Products of this project	Publications (27 results)

15. Comparative Studies on Metabolism and Physiological Activity of the Vitamin D_2 and D_3 Related Compounds

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	Kobe Women's College of Pharmacy
Principal Investigator	KOBAYASHI Tadashi Ph.D. Professor of Kobe Women's College of Pharmacy
Project Period (FY)	1986 – 1988Completed
Keywords	Vitamin D / Vitamin D_2 / Vitamin D_3 / 25-Hydroxyvitamin D / 24,25-Dihydroxyvitamin D / 1,25-Dihydroxyvitamin D / Vitamin D-Binding Protein
Research Abstract	Comparative studies on metabolism and physiological action of the vitamin D_2 and D_3 Related compounds were performed.

Research Products of this project	Publications (29 results)