KAKEN — Research Projects | Researcher Number: 70436541

Search Results: 7 results / Researcher Number: 70436541

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1. 時空間ドーズを管理する「貼るだけクロノワクチン」技術基盤の創生

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 90120:Biomaterials-related
Research Institution	Institute of Science Tokyo
Principal Investigator	松元亮東京科学大学, 総合研究院, 教授
Project Period (FY)	2025-04-01 – 2028-03-31Granted
Keywords	ワクチン / 開裂化学 / スケジューリング / マイクロニードル
Outline of Research at the Start	近年、ワクチン投与において、抗原やアジュバントの時空間パターンを「週」規模で持続的に制御する“スケジューリング”の重要性が明らかになっている。最近我々は、ボロン酸とジエタノールアミン誘導体との平衡反応で形成される構造体において、その開裂速度を、秒・分・時間・日・週・月に渡って自在に設定可能な開裂反応 ...

2. mRNA therapy for the treatment of autoimmune diseases that produces chimeric antigen receptor regulatory T cells in vivo

Research Project

Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Review Section	Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Research Institution	The University of Tokyo
Principal Investigator	Cabral Horacio 東京大学, 大学院工学系研究科(工学部), 准教授
Project Period (FY)	2022-06-30 – 2024-03-31Completed
Keywords	mRNA / polymeric micelles / in situ Treg / Immunosuppression / Treg / Foxp3 / in vivo CAR T / nanomedicine / immunotherapy / autoimmune disease
Outline of Research at the Start	Herein, we will prepare mRNA-loaded micelles for generating CAR-Tregs in vivo. In the first year, we will prepare the micelles and check the ability t ...
Outline of Final Research Achievements	Herein, we used polymeric micelles installed with anti-CD3 F(ab')2 antibodies to effectively deliver mRNA to T cells, aiming to induce the production ...

Research Products of this project	Journal Article (9 results, of which Int'l Joint Research: 9 results, Peer Reviewed: 9 results, Open Access: 8 results) Book (1 results)

3. Development of artificial transporter making use of boronic acid molecular recognition

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 90120:Biomaterials-related
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Matsumoto Akira 東京医科歯科大学, 生体材料工学研究所, 教授
Project Period (FY)	2020-04-01 – 2023-03-31Completed
Keywords	ボロン酸 / シアル酸 / がん幹細胞 / 弱酸性化 / 低酸素環境 / 二リン酸 / 核酸擬似体 / リポソーム / ビタミン / がん / がん幹細胞様細胞
Outline of Research at the Start	本研究は、薬剤または生理活性物質のデリバリーを念頭に、治療効果と安全性を最大化するための「人工トランスポーター」の開発を目的とする。申請者らが最近発見したピリジル系ヘテロ環含有ボロン酸による「プロドラッグ構造（二リン酸）および腫瘍環境に特徴的な弱酸性条件下でのみ顕在化するシアル酸認識能」を応用し、全 ...
Outline of Final Research Achievements	We discovered some pyridyl-containing heterocyclic boronic acid derivatives are able to bind to sialic acids tens of times more potent and selectively ...

Research Products of this project	Journal Article (21 results, of which Peer Reviewed: 21 results, Open Access: 2 results) Presentation (16 results, of which Int'l Joint Research: 3 results, Invited: 10 results) Patent(Industrial Property Rights) (2 results, of which Overseas: 1 results)

4. Development of ion-sequensing method using boronic acid

Research Project

Research Category	Grant-in-Aid for Young Scientists (A)
Research Field	Biomedical engineering/Biomaterial science and engineering
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Matsumoto Akira 東京医科歯科大学, 生体材料工学研究所, 准教授
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	ボロン酸 / ピロリン酸 / 核酸増幅 / シーケンサー / 生体計測 / DNA
Outline of Final Research Achievements	We found that a heterocyclic class of boronic acids, based on the pyridine structures, can interact with pyrophosphate and some of its derivatives in ...

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 5 results, Acknowledgement Compliant: 5 results, Open Access: 2 results) Presentation (25 results, of which Int'l Joint Research: 12 results, Invited: 15 results)

5. Smart-gel based synthetic artificial pancreas

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Biomedical engineering/Biomaterial science and engineering
Research Institution	Tokyo Medical and Dental University
Principal Investigator	MATSUMOTO Akira 東京医科歯科大学, 生体材料工学研究所, 准教授
Project Period (FY)	2013-04-01 – 2015-03-31Completed
Keywords	ゲル / ボロン酸 / 糖尿病 / グルコース / インスリン / 高分子ゲル
Outline of Final Research Achievements	This study aims to develop a functionalized gel based synthetic insulin delivery system to treat diabetes. A prototype device was fabricated by covale ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 4 results, Open Access: 2 results, Acknowledgement Compliant: 3 results) Presentation (26 results, of which Invited: 11 results) Book (3 results)

6. Development of Integrated Transistor Based device for Monitoring of Enzymatic Activities as Next-generation Platform for Apoptosis Pathways Analysis

Research Project

Research Category	Grant-in-Aid for Young Scientists (A)
Research Field	Biomedical engineering/Biological material science
Research Institution	Tokyo Medical and Dental University
Principal Investigator	MATSUMOTO Akira 東京医科歯科大学, 生体材料工学研究所, 准教授
Project Period (FY)	2011-04-01 – 2014-03-31Completed
Keywords	電界効果トランジスタ / アポトーシス / カスパーゼ / 酵素活性 / パスウェイ解析
Research Abstract	We envisioned the development of an integrated transistor based device that is able to quantify enzymatic activities in cells. Caspase-3 and -8 were ...

Research Products of this project	Journal Article (15 results, of which Peer Reviewed: 6 results) Presentation (16 results, of which Invited: 4 results) Book (12 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results, of which Overseas: 4 results)

7. Design of Semiconductor/Biology Nano-Interface for Development of Genetic Transistor

Planned Research

Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Review Section	Science and Engineering
Research Institution	Tokyo Medical and Dental University (2010-2012) National Institute for Materials Science (2008-2009)
Principal Investigator	MIYAHARA Yuji 東京医科歯科大学, 生体材料工学研究所, 教授
Project Period (FY)	2008 – 2012Completed
Keywords	バイオトランジスタ / スマートゲル / 含水率 / フェニルボロン酸 / 高分子ゲル / 電界効果トランジスタ / 動的ナノ界面 / コンカナバリンA / トランジスタ / 刺激応答性ゲル / 動的界面 / 信号変換 / デバイ長 / 二重応答性 / グルコース応答FET
Research Abstract	We demonstrated an ability of stimuli-responsive polymer gels as nano-interfaces enabling a FET-based, but nonetheless virtually “Debye length-free” u ...
Project Area	Molecular Soft-Interface Science

Research Products of this project	Journal Article (14 results, of which Peer Reviewed: 7 results) Presentation (33 results, of which Invited: 7 results) Book (13 results) Remarks (3 results)