| Budget Amount *help |
¥74,100,000 (Direct Cost: ¥57,000,000、Indirect Cost: ¥17,100,000)
Fiscal Year 2012: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2011: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2010: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2009: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2008: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Research Abstract |
RIG-1-like receptors(RLRs)are viral RNA sensors, which initiate antiviral innate immunity. In this work, we tried to elucidate molecular machinery underlying RNA recognition by RLRs and physiological significance of RLR-mediated signaling. We revealed 1)accumulation of RLRs in stress granule-like aggregates to trigger antiviral signaling, 2) inhibition of viral infection via induction of specific microRNA, which downregulates viral receptor expression and 3)possible interaction of RIG-I with endogenous self RNA. These observations made substantial progress for understanding of biological function of RLRs.
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