| Budget Amount *help |
¥121,030,000 (Direct Cost: ¥93,100,000、Indirect Cost: ¥27,930,000)
Fiscal Year 2012: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2011: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2010: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2009: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2008: ¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000)
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| Research Abstract |
The purpose of this project was to propose theoretical frameworks of how nuclear environment("genofield")affects genetic activities. Using Caenorhabditis elegans as a model organism, I quantified spatial parameters on genofield, and constructed simulation models that reproduce the quantified features of genofield. I focused on the sizes of cells and nucleus as the spatial parameters, and quantified how the changes in these parameters affect storage of genetic information into chromosomes and mitotic spindles. Based on the quantification, I reproduced these quantitative relationships of genofield in silieo.
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