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Experimental and clinical study of the ventricular late-potential

Research Project

Project/Area Number 02454252
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionYamagata University

Principal Investigator

IKEDA Kozue (1992)  Yamagata Univ. Sch of Med, Assis. Prof., 医学部, 助手 (30184419)

久保田 功 (1991)  山形大学, 医学部, 講師 (30161673)

立木 楷 (1990)  山形大学, 医学部, 助教授 (30004683)

Co-Investigator(Kenkyū-buntansha) OHTA Ikurou  Yamagata Univ, Sch of Med, Assis. Prof., 医学部, 講師 (70143097)
OGUMA Masaki  Yamagata Univ, Sch of Med, Assis. Prof., 医学部, 講師 (10160821)
YAMAKI Michiyasu  Yamagata Univ, Sch of Med, Assis. Prof., 医学部, 助手 (40191217)
池田 こずえ  山形大学, 医学部, 助手 (30184419)
久保田 功  山形大学, 医学部, 講師 (30161673)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥4,700,000 (Direct Cost: ¥4,700,000)
KeywordsSignal-averaged ECG / Body surface mapping / Epicardial mapping / Myocardial infarction / Ventricular tachycardia / Spectral analysis / 心室遅延電位 / 心電図加算 / フ-リエ変換 / 逆フ-リエ変換
Research Abstract

To investigate the body surface distribution of high-and low frequency components within the QRS complex and ventricular tachycardia (VT), 87 signal-averaged ECGs were obtained from normal subjects (N group)and 30 patients with previous anterior myocardial infarction with VT (MI-VT(+) group, n=10) or without VT (MI-VT(-) group, n=20). Fast fourier transform analysis was performed on signal-averaged ECG. Then, inverse transform was done with five frequency ranges (0-25, 25-40, 40-80, 80-125, and 125-250 Hz). From the QRS onset to QRS offset, the time integration of the absolute value of reconstructed waveforms was calculated for each frequency range. Both MI groups had significantly smaller maximal values in the frequency ranges of 25-40 and 40-80 Hz compared with the N group. The MI-VT(+) group had significantly smaller maximal values in the frequency ranges of 40-80 and 80-150 Hz than in the MI-VT(-) group.
Spectral analysis was also performed in 8 mongrel dogs with 4-week-old myocardial infarction (MI group) and 6 sham-operated dogs (N group). Left anterior descending coronary artery was ligated under aseptic surgery. Four weeks after, 60-lead epicardial electrograms were recorded, and spectral analysis of QRS complex was performed. On the frequency ranges of 25-40, 40- 80, 80-150, and 125-250 Hz, MI group had significantly smaller values than N group in the infarcted zone. However, in the non-infarcted zone, there was no significant difference between the MI and N group.
It was demonstrated that high-frequency components were reduced in the QRS complex on the body surface ECGs and epicardial electrograms after myocardial infarction. This reduction might indicate the loss of electrical forces and abnormal conduction in the myocardial scar, and might be related to the ventricular tachycardia.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report

Research Products

(13 results)

All Other

All Publications (13 results)

  • [Publications] Kubota,Isao et al.: "Body surface signal-averaged P maps in normal subjects and patients with valvular heart disease" Am J Noninvas Cardiol. 6. 129-133 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hosoya,Yukio et al.: "Spectral analysis of 87-lead body surface signal-averaged ECGs in patients with previous myocardial infarction as a marker of ventricular tachycardia" Circulation. 85. 2060-2064 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kubota,Isao et al.: "Spectral analysis of the first half QRS complex in normal Subjects and patients with previous myocardial infarction" Am J Noninvas Cardiol. 6. 104-108 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kubota,Isao et al: "Body surface signal-averaged P maps in normal subjects and patients with valvular heart disease" Am J Noninvas Cardiol. 6. 129-133 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hosoya,Yukio et al: "Spectral analysis of 87-lead body surface signal-averaged ECGs in patients with previous myocardial infarction as a marker of ventricular tachycardia" Circulation. 85. 2060-2064 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kubota,Isao et al: "Spectral analysis of the first half QRS complex in normal subjects and patients with previous myocardial infarction" Am J Nonivas Cardiol. 6. 104-108 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kubota,Isao et al.: "Body surface signal-averaged P maps in normal subjects and patients with valvular heart disease" Am J Noninvas Cardiol. 6. 129-133 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hosoya,Yukio et al.: "Spectral analysis of 87-lead body surface signal-averaged ECGs in patients with previous myocardial infarction as a marker of ventricular tachycardia" Circulation. 85. 2060-2064 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kubota,Isao et al.: "Spectral analysis of the first half QRS complex in normal Subjects and patients with previous myocardial infarction" Am J Noninvas Cardiol. 6. 104-108 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yukio Hosoya,et al.: "Spectral Analysis of 87ーLead Body Surface Electrocardiograms in Patients with Previous Anterior Myocardial Infarction for the Prediction of Ventricular Tachycardia" Circulation. 85. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yukio Hosoya,et al.: "Spectral Analysis of Epicardial 60ーLead Electrocardiograms in Dogs with 4ーWeek Myocardial Infarction" Japanese Circulation Journal. 55. 32 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yukio Hosoya,et al.: "Spectral Analysis of 87ーlead Body Surface Signal Averaged Electrocardiograms in Patients with Previous Anterior Myocardial Infarction for the prediction of Ventricular Tachycardia" Japanese Circulation Journal. 55. 285 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takehiko Shibata,Isao Kubota,Kozue Ikeda,Kai Tsuiki,Shoji Yasui: "Body Surfacc mapping of highーfrequency components in the terminal portion during,QRS comples for the prediction ofventricular tachycardia in patients with previous myocardial infarction" Circulation. 82. 2084-2092 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-03-31   Modified: 2016-04-21  

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