| Project/Area Number |
02670563
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ISHIKAWA Akio Institute of Clinical Medicine Assistant Professor, 臨床医学系, 講師 (50134226)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Masayuki The Research Center for Pathologic Fungi and Microbial Toxicoses, Chiba Universi, 真核微生物研究センター, 助教授 (00092073)
TANAKA Einosuke Institute of Community Medicine University of Tsukuba Assistant Professor, 社会医学系, 講師 (30138416)
OHHRA Kiyoshi Institute of Clinical Medicine University of Tsukuba Associate Professor, 臨床医学系, 助教授 (10034125)
FUKAO Katashi Institute of Clinical Medicine University of Tsukuba Associate Professor, 臨床医学系, 助教授 (50091921)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | hepatocellular carcinoma / Localized radiotherapy on the liver / Hepatic microsomal function / Hepatic functional reserve |
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| Research Abstract |
Fundamental Study
The estimation of hepatic microsomal function using TMO tolerance test and pathological examination after the irradiation on hepatic parenchyma were studied in rats. The DMO/TMO ratios one month after the 40 Gy irradiation were 0.56<plus-minus>0.10 in irradiated rats and 0.38<plus-minus>0.06 in controls, respectiv
The DMO/TMO ratios ten months after the 40 Gy irradiation were 0.53 <plus-minus>0.08 in irradiated rats and 0.64<plus-minus>0.08 in controls, respectiv
The hepatic microsomal function of irradiated rats decreased at three, six and ten months after 40 Gy irradiation.
Histological examinations revealed that the irradiated livers contained mild atrophy and the irregularity of chromatin nucleoli in hepatocytes three, six and ten months after the 40 Gy irradiation.
Clinical Study of radiotherapy on hepatocellular carcinoma
Localized radiotherapy was performed for eighteen patients with hepatocellular carcinoma. The tumor volume was decreased in eleven patients.
AFP was decreased in twelve, of these fourteen patients.
However, the hepatic microsomal function not decreased after the radiotherapy in these patients.
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