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Effects of acidic fibroblast growth factor released by feeding on learning and memory, endocrine and immune systems

Research Project

Project/Area Number 09470015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionToyama University

Principal Investigator

SASAKI Kazuo  Toyama University・Faculty of Engineering, Professor, 工学部, 教授 (60042826)

Co-Investigator(Kenkyū-buntansha) TSUKADA Akira  Toyama University・Faculty of Engineering, Assistant Professor, 工学部, 助手 (40236849)
KAWARADA Atsushi  Toyama University・Faculty of Engineering, Associate Professor, 工学部, 助教授 (80195164)
ISOBE Masaharu  Toyama University・Faculty of Engineering, Professor, 工学部, 教授 (70211050)
大村 裕  日本臓器製薬(株), 生物活性研, 常勤顧問 (30019517)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1997: ¥7,500,000 (Direct Cost: ¥7,500,000)
Keywordsacidic fibroblast growth factor / learning and memory / endocrine system / immune system / 線維芽細胞増殖因子 / 老化促進モデルマウス / アドレナリン / マクロファージ / コルチコステロン / 遺伝子
Research Abstract

1. Effect of aFGF and its fragment on learning and memory : It is well known that senescence-accelerated mice (SAMP8) have a deteriorated ability on learning and memory. In the present study, SAMP8 received s.c. injections of aFGF or its fragment. The injections were started after weaning at 21 days of age and repeated once a week for 10 months. Consequently, aFGF or its fragment significantly improved the ability on learning and memory of SAMP8, when examined with passive avoidance test and Morris water maze test. The beneficial effect of aFGF and its fragment on learning and memory function in SAMP8 may be related to a preservation of function in medial septum cholinergic neurons.
2. Effect of aFGF on endocrine system : I.c.v. injections of aFGF in rats significantly increased plasma corticosterone level and plasma adrenaline level. Pre-I.c.v. injections of anti-CRF antibody before aFGF injections abolished the increase of plasma corticosterone and adrenaline levels. Thus, it may be possible to state that aFGF activates hypotlhlamic-pituitary-adrenocortical axis and adrenomedullary secretion through CRF.
3. Effect of aFGF and its fragments on immune system : Action of aFGF and its fragments on phagocytosis of peritoneal macrophages in rats was investigated by flow cytometry. The results indicate that aFGF, aFGF(1-20) and aFGF(1-29) dose-dependently activate phagocytosis of macrophages.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Yasuyuki Nomura: "Alterations in acetylcholine, NMDA, benzodiazepine receptors and protein kinase C in the brain of the senescence-accelerated mouse : an animal model useful for studies on cognitive enhancers"Bahav. Brain Res.. 83. 51-55 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikuo Tooyama: "Effect of acidic fibroblast growth factor on basal forebrain cholinergic neurons in senescence-accelerated mice"Exp. Gerontol.. 32. 171-179 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuyuki Ichinose: "Effect of acidic fibroblast growth factor(aFGF) on phagocytosis in mouse peritoneal macrophages"Microbiol. Immunol.. 42. 139-142 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Itsuro Matsumoto: "Acidic fibroblast growth factor activates hypothalamic-pituitary-adrenocortical axis in rats"Am. J. physiol.. 274. R503-R509 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuyuki Ichinose: "Enhancement of phagocytosis in mouse peritoneal macrophages by fragments of acidic fibroblast growth factor(aFGF)"Int. J. Immunopharmacol.. 20. 193-204 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Itsuro Matsumoto: "Acidic fibroblast growth factor activates adrenomedullary secretion and sympathetic outflow in rats"Am. J. Physiol.. 275. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ai-Jun Li: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor"Neuroscience. 85. 785-794 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuyuki Ichinose: "Induction of outward current by orexin-B in mouse peritoneal macrophages"FEBS Lett.. 440. 51-54 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takemasa Shiraishi: "Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats"Nutrition. 15. 576-579 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kazuo Sasaki: "Effects of acidic fibroblast growth factor fragment analog on learning and memory and on medical septum cholinergic neurons in rats"Neuroscience. 92. 1287-1294 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ai-Jun Li: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two takes in gerbils"Physiol. & Behav.. 66. 577-583 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasuyuki Nomura et al.: "Alterations in acetylcholine, NMDA, benzodiazepine receptor and protein kinase C brain of the senescence-accelerated mouse : an animal model useful for studies on cognitive enhancers"Behav.Brain Res.. 83. 51-55 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikuo Tooyama et al.: "Effect of acidic fibroblast growth factor on basal forebrain cholinergic neurons in senescence-accelerated mice"Exp.Gerontol.. 32. 171-179 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuyuki Ichinose et al.: "Effect of acidic fibroblast growth factor (aFGF) on phagocytosis in mouse peritoneal macrophages"Microbiol.Immunol.. 42. 139-142 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Itsuro Matsumoto et al.: "Acidic fibroblast growth factor activates hypothalamic-pituitary-adrenocortical axis in rats"Am.J.Physiol.. 274. R503-R509 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuyuki Ichinose et al.: "Enhancement of phagocytosis in mouse peritoneal macrophages by fragments of acidic fibroblast growth factor (aFGF)"Int.J.Immunopharmacol.. 20. 193-204 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Itsuro Matsumoto et al.: "Acidic fibroblast growth factor activates adrenomedullary secretion and sympathetic outflow in rats"Am.J.Physiol.. 275. R1003-R1012 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ai-Jun Li et al.: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor"Neuroscience. 85. 193-204 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mitsuyuki Ichinose et al.: "Induction of outward current by orexin-B in mouse peritoneal macrophages"FEBS Lett.. 440. 576-579 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tkemasa Shiraishi et al.: "Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats"Nutrition. 15. 576-579 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kazuo Sasaki et al.: "Effects of acidic fibroblast growth factor fragment analog on learning and memory and on medical sptum cholinergic neurons in rats"Neuroscience. 92. 1287-1294 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ai-Jun Li et al.: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils"Physiol.& Behav.. 66. 577-583 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takemasa Shiraishi: "Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats"Nutrition. 15. 576-579 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kazuo Sasaki: "Effects of acidic fibroblast growth factor fragment analog on learning and memory and on medial septum cholinergic neurons in"Neuroscience. 92. 1287-1294 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ai-Jun Li: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbits"Physiology & Behavior. 66. 577-583 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Itsuro Matsumoto: "Acidic fibroblast growth factor activates hypothalamic-pituitary-adrenocortical axis in rats" Am. J. Physiol.274. R503-R509 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mitsuyuki Ichinose: "Enhancement of phagocytosis in mouse peritoneal macrophages by fragments of acidic fibroblast growth factor (aFGF)" Int. J. Immunopharmacol.20. 193-204 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Itsuro Matsumoto: "Acidic fibroblast growth factor activates adrenomedullary secretion and sympathetic outflow in rats" Am. J. Physiol.275. R1003-R1012 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ai-Jun Li: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks:contribution of acidic fibroblast growth factor" Neuroscience. 85. 785-794 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mitsuyuki Ichinose: "Induction of outward current by orexin-B in mouse peritoneal macrophages" FEBS Lett.440. 51-54 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yasuyuki Nomura: "Alterations in acetylcholine,NMDA,benzodiazepine receptors and protein kinase C in the brain of the senescence-accelerated mouse:an animal model useful for studies on cognitive enhancers" Behav.Brain.Res.83. 51-55 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikuo Tooyama: "Effeot of acidic fibroblast groioth factor on basal forebrain chclinergic meurons in sensccnce-accelerated mice" Exp.Grrontol.32. 171-179 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mitsuyuki Ichinose: "Effect of acidic fibrublast growth factor(aFGF)on phagocytosis in mouse peritoneal macrophages" Microbiol.Immunol.42. 139-142 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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