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Physicochemical and molecularbiological modification of artificial joint surfaces used the compromised patients

Research Project

Project/Area Number 09470321
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOSAKA CITY UNIVERSITY

Principal Investigator

KITANO Toshio  Osaka City Univ., Dept.Orthop., Assist.Prof., 医学部, 助手 (50291597)

Co-Investigator(Kenkyū-buntansha) KADOYA Yoshinori  Osaka City Univ., Dept.Orthop., Lecturer, 医学部, 講師 (20204521)
OOHASH Hirotugu  Osaka City Univ., Dept.Orthop., Lecturer, 医学部, 講師 (70254406)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
KeywordsTOTAL JOINT REPLACEMENT / SURFACE MODIFICATION / INFECTION / LUBRICATION / ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE / POLYCRYSTAL ALUMINA CERAMIC / 生体材料 / 感染 / 表面処理 / 表面自由エネルギー / 感染症 / 炎症性関節液 / ゼータ電位 / 細菌
Research Abstract

Total joint replacement for the compromised patients has the higher ratio of complication. It can be speculated that the reduction of surface free energy would decrease friction coefficient of artificial joint surfaces and adsorption of bacterium. Fluoroalkylation is one of the surface modification methods, decreasing surface free energy.
It has been hypothesized that modification of biomaterial used for total replacement joint surfaces may decrease coefficient of friction (CF) and adsorption of bacterium as a result of decreasing surface free energy. The purpose of this study is to test this hypothesis, assessing the CF of modified Ultra-High Molecular Weight Polyethylene (UHMWPE) and Polycrystal Alumina Ceramic (PCAC).
UHMWPE and PCAC were fluoroalkylated using fluoroalkyl end-capped silane coupler. Decreasing surface free energy and fluoroalkylation for biomaterial were confirmed. CF between UHMWPE and PCAC (control or modified) was measured with a mechanical spectrometer using disc on disc geometry with changing of angular velocity. A vertical load was applied on the disc at 250 kPa. CF of modified PCAC against UHMWPE was significantly decreased at all range of angular velocity.
Fluoroalkylation is an easy method of surface modification that polymerizes fluoroalkyl group on material surface in very thin layer. There has a possibility of clinical use in fluoroalkylation for biomaterial to resolve complications following total joint arthroplasty.

Report

(3 results)
  • 2000 Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] KITANO.Toshio: "Changes of the properties of colloids in arthritic synovial fluia"Hydrocolloids. 2. 331-336 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 北野利夫: "摺動面に使用する人工材料のフルオロアルキル化による低摩擦性の獲得"日本人工関節学会誌. 30. 5-6 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 北野利夫: "生体関節及び人工関節表面において疑似関節液中の蛋白質成分とPH値が境界潤滑特性に与える影響の比較"日本臨床バイオメカニクス学会誌. 21. 1-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toshio Kitano: "Changes of the properties of colloids in arthritic synovial fluid"Hydrocolloids. 2. 331-336 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toshio Kitano: "Low coefficient of friction of the Artificial joint surfaces using Fluoroalkylation"The Japanes Society for Replacement arthoroplasty. 30. 5-6 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toshio Kitano: "Effect of pH and protein constituents In quasi-synovial fluid on boundary Lubrication in artificial and natural joint surface model"The Japanes Society for Clinical Biomechanics and Related Research. 21. 1-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary

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Published: 1998-04-01   Modified: 2016-04-21  

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