| Project/Area Number |
10671922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Tohoku University |
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Principal Investigator |
SAITO Takashi Dental Hospital, Tohoku University Associate Professor, 歯学部・附属病院, 助教授 (90005108)
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| Co-Investigator(Kenkyū-buntansha) |
ONODERA Kenji School of Dentistry, Tohoku University Lecturer, 歯学部, 教授 (40133988)
TAGASAWA Masumi Dental Hospital, Tohoku University Assistant, 歯学部・附属病院, 助手 (70271955)
IGARI Kazuko Dental Hospital, Tohoku University Lecturer, 歯学部・附属病院, 講師 (90125493)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | epilepsy / bone mineral density / anti-epileptic drug / tooth formation / osteoporosis / 骨減少症 |
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| Research Abstract |
In order to investigate whether the formation of teeth and alveolar bones is affected by the long administration of anti-epileptic drugs, 14 outpatients with epilepsy were selected. They were examined by questionnaire, study model, occlusal and band X-ray photography. Subjects were 3 male and 11 female patients aged 11 to.28(average 19.6 years). Most of them have administered phenytoin, zonisamide and sodium valproate during 11- 20 year or longer. As the period of administration was longer, bone mineral density of hand bone was declined. We tried to examine bone mineral density of alveolar bone and degree of teeth calcification, but it was very difficult to analyze them with as the same method as hand bone. It seems that bone mineral density of alveolar bone acts corresponding with hand bone.
On the other hand, we experimented the effects of long-term administration of phenytoin (20mg/kg/day) or zonisamide (80mg/kg/day) every day during 5 weeks using rats. Bone mineral density of phenytoin group and zonisamide group was decreased. Combined administration of 1α (OH)DィイD23ィエD2 or 1α, (OH)ィイD22ィエD2DィイD23ィエD2 inhibited these decrease. The animal model could be useful to elucidate the mechanism of osteopenia induced by anti-epileptic drugs.
It is considered that a long administration of anti-epileptic drugs from the earliest childhood affects tooth formation. We are developing another method analyzing teeth and alveolar bone.
The results suggest that anti-epileptic drugs decline bone mineral density, and it is careful not to fracture the bone when we treat a dental care to patient with epilepsy.
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