| Project/Area Number |
11671487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yamanashi Medical University |
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Principal Investigator |
KASHIMOTO Satoshi Yamanashi Medical University, Department of Anesthesiology, Associate Professor, 医学部, 助教授 (60152633)
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| Co-Investigator(Kenkyū-buntansha) |
IIJIMA Tetuya Yamanashi Medical University, Department of Anesthesiology, Instructor, 医学部, 助手 (70324209)
OGUCHI Takeshi Yamanashi Medical University, Department of Anesthesiology, Assistant Professor, 医学部, 講師 (60201399)
野中 明彦 山梨医科大学, 医学部, 講師 (90228338)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Neuropathic Pain / c-fos / partial nerveinjury model / CCIモデル / c-Fos |
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| Research Abstract |
Malmberg (1998) demonstrated that C57BL6 mice, which received a tight ligature aroud 1/3 to 1/2 of the diameter of the sciatic nerve, can be used as a model of neuropathic pain. We tied the same ligature around the sciatic nerve of Std : ddy mice. The mice, which received the partial sciatic nerve injury, tend to show the threshold changes on thermal and mechanical stimuli.
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