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Vitamin A modulates the effect of estrogen on cell differentiation

Research Project

Project/Area Number 13640662
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 生物形態・構造
Research InstitutionThe University of Tokyo

Principal Investigator

MORI Takao  The University of Tokyo, Graduate School of Science, Professor, 大学院・理学系研究科, 教授 (80011659)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsmouse / vaginal epithelium / epididymis / estrogen / vitamin A / endocrine disruptor / 内分泌攪乱物質 / エストロゲン受容体
Research Abstract

In this study, we introduced estrogen and bisphenol as an endocrine disruptor and vitamin A as an inhibitor of the effect of such endocrine disrupters on the developing reproductive system in female and male mice. The results also suggested that, to a certain extent, the replenishment of vitamin A-rich food is important for relieving the effect of endocrine disruption in babies, caused by exogenous estrogenic substances, since the effect of such substances on the developing reproductive tracts should exert via vitamin A deficiency. On the other hand, unusual mRNA expression of a cellular retinol binding protein 2, which regulates the metabolism of vitamin A, was found in the reproductive tracts after neonatal exposure to estrogen. Therefore, it could be proposed that the neonatal effects of both estrogen and bisphenol A on the vaginal differentiation and spermatogenesis are exerts through the suppression of vitamin A action. Although the interaction of vitamin A with estrogenic substances during a critical period was not clarified, a possible explanation is conceivable : 1) at first, neonatal treatment with estrogenic substances leads to the disruption of vitamin A metabolism and/or transportation in the reproductive tracts ; 2) the direction of normal differentiation of the reproductive tracts is changed by a lack of appropriate vitamin A action ; 3) the reproductive tracts, of which the direction of normal differentiation is changed, receive the continuing estrogenic stimulation as a proliferation signal ; and 4) the reproductive tracts differentiate to an abnormal direction.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] K.Nakahashi et al.: "Vitamin A insufficiency accelerates the decrease in the number of sperm induced by bisphenol A"Zoological Science. 18. 819-821 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] F.Masui et al.: "Prevention of neonatal estrogen imprinting by vitamin A as indicated by estrogen receptor expression"Cell Tissue Research. 306. 441-447 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Wanichacheewa et al.: "Decrease in the number of sperm associate with decreased blood testosterone levels in male rats"Journal Environmental Toxicology and Pharm. 10. 1-4 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Akazome et al.: "Differentiation of chicken gonad as an endocrine organ: expression of LH receptor and aromatase genes"Reproduction. 123. 721-728 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Mori et al.: "Priming effects of novel nonsteroidal progesterone receptor modulators on the development of adenomyosis"Life Sciences. 71. 527-535 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] F.Mosai et al.: "Vitamin A prevents the irreversible proliferation of the vaginel epithelium induced neonatal al KGF"Cell Tissue Research. 311(in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Nakahashi, M. Matsuda and T. Mori: "Vitamin A insufficiency accelerates the decrease in the number of sperm induced by an environmental disrupter, bisphenol A, in neonatal mice"Zoological Science. 18. 819-821 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] F. Masui, M. Matsuda, Y. Akazome, T. Imaoka and T. Mori: "Prevention of neonatal estrogen imprinting by vitamin A as indicated by estrogen receptor expression in the mouse vagina"Cell Tissue Research. 306. 441-447 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Wanichacheewa, T. Singtripop, S. Sassa, S. Sakamoto and T. Mori: "Decrease in the number of sperm associated with decreased blood testosterone levels in male rats treated with extracts from seven plants consumed by natives of northern Thailand"J. Enviromental Toxicology and Pharamcology. 10. 1-4 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. Akazome, T. Abe and T. Mori: "Differentiation of chicken gonad as an endocrine organ : expression of LH receptor, FSH receptor, cytochrome P450c17 and aromatase genes"Reproduction. 123. 721-728 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Mori, Y. Kurata, Y. Tabata, N. Niho, M. Matsuda and Y-F. Zhou: "Priming effects of novel nonsteroidal progesterone receptor modulators CP8816 and CP8863 on the development of adenomyosis in the mouse uterus"Life Science. 71. 527-535 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] F. Masui, M. Matsuda and T. Mori: "Vitamin A prevents the irreversible proliferation of vaginal epithelium induced by neonatal injection of keratinocyte growth factor in mice"Cell Tissue Res.. 311: in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Imaoka et al.: "Cortactin-binding protein 90 expression in the mouse MG during prolactin-induced lobuloalveolar development"Zoological Science. 19. 443-448 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Kuwa et al.: "UFT and mammary tumors in rederts"Medical Postgraduates. 40. 274-279 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Akazome et al.: "Differentiation of chicken gonad as an endocrine organ: expression of LH-R, FSH-R, cytochrome P450c17 and aromatase genes"Reproduction. 123. 721-728 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Mori et al.: "Priming effects of novel nonsteroidal progesterone receptor modulators on the development of adenomyosis in the mouse uterus"Life Sciences. 71. 527-535 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Mori et al.: "A matrix metalloproteinase inhibitor, ONO-4817, retards the development of MT and the progression of adenomyosis in mice"Anticancer Research. 22. 3985-3988 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] F.Masui et al.: "Vitamin A prevents the irreversible proliferation of vaginal epithelium induced by nenatal injection of KGF"Cell Tissue Research. 187(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] F.Masui, et al.: "Prevention of neonatal estrogen imprinting by vitamin A as indicated by estrogen receptor expression in the mouse vagina"Cell Tissue Research. 306. 441-447 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Nakahashi, et al.: "Vitamin A insufficiency accelerates the decrease in the number of sperm induced by an environmental disruptor in neonatal mice"Zoological Science. 18. 819-821 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Wanichacheewa, et al.: "Decrease in the number of sperm associated with decreased blood testos-terone levels in male rats treated with extracts from seven plants"Environmental Toxicology and Pharmacology. 10. 1-4 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Mori, et al.: "Suppression of the development of experimentally induced uterine adenomyosis by a novel matrix metalloproteinase inhibitor, ONO-4817"Experimental Biology and Medicine. 226. 429-433 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Nonaka, et al.: "Novel androgen-dependent promoters direct expression of the C4b-bindng protein α-chain gene in epididymis"Journal of Immunology. 166. 4570-4577 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Matsuda, et al.: "Increased invasion activity of endometrial stromal cells and elevated expression of MMP mRNA in the uterine tissues of mice"American Journal of Obstetrics and Gynecology. 185. 1374-1380 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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