| Project/Area Number |
15H04281
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松田 達志 関西医科大学, 医学部, 准教授 (00286444)
依馬 正次 滋賀医科大学, 動物生命科学研究センター, 教授 (60359578)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI SATORU 筑波大学, 医学医療系, 教授 (50271896)
OMIYA YOSHIHIRO 産業技術総合研究所, バイオメディカル研究部門, 部門長 (20223951)
ISHIHARA MIYA 防衛医科大学, 医学教育部, 教授 (30505342)
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| Research Collaborator |
KIJIMA JUNKO 筑波大学, 医学医療系, 技術職員 (30517793)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 蛍光 / 非侵襲 / モデルマウス / 近赤外 / イメージング / マウス / 蛍光イメージング / タンパク質分解 |
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| Outline of Final Research Achievements |
By developing degradation-regulated NIR fluorescent probe, we have realized high time resolution non-invasive imaging with living model mice. We have also developed fluorescent-bioluminescent dual imaging method. Furthermore, we applied established model mice. In future, these techniques would be very powerful approach for analysis of diseases and drug discovery.
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