Development and application of advanced non-invasive imaging system for mice
| Project/Area Number |
15H04281
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松田 達志 関西医科大学, 医学部, 准教授 (00286444)
依馬 正次 滋賀医科大学, 動物生命科学研究センター, 教授 (60359578)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI SATORU 筑波大学, 医学医療系, 教授 (50271896)
OMIYA YOSHIHIRO 産業技術総合研究所, バイオメディカル研究部門, 部門長 (20223951)
ISHIHARA MIYA 防衛医科大学, 医学教育部, 教授 (30505342)
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| Research Collaborator |
KIJIMA JUNKO 筑波大学, 医学医療系, 技術職員 (30517793)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 蛍光 / 非侵襲 / モデルマウス / 近赤外 / イメージング / マウス / 蛍光イメージング / タンパク質分解 |
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| Outline of Final Research Achievements |
By developing degradation-regulated NIR fluorescent probe, we have realized high time resolution non-invasive imaging with living model mice. We have also developed fluorescent-bioluminescent dual imaging method. Furthermore, we applied established model mice. In future, these techniques would be very powerful approach for analysis of diseases and drug discovery.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Fluorescence and Bioluminescence imaging of angiogenesiss in Flk1-nano-lantern Transgenic mice2017
Author(s)
Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani KI, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M
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Journal Title
Sci. Rep
Volume: 7
Issue: 1
Pages: 46597-46597
DOI
Related Report
Peer Reviewed
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[Journal Article] Simple generation of hairless mice for <i>in vivo</i> imaging2017
Author(s)
HOSHINO Yoshikazu、MIZUNO Seiya、KATO Kanako、MIZUNO-IIJIMA Saori、TANIMOTO Yoko、ISHIDA Miyuki、KAJIWARA Noriko、SAKASAI Tomoki、MIWA Yoshihiro、TAKAHASHI Satoru、YAGAMI Ken-ichi、SUGIYAMA Fumihiro
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Journal Title
Experimental Animals
Volume: 66
Issue: 4
Pages: 437-445
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nuclear factor (erythroid derived 2)-like 2 activator increases exercise endurance capability via redox-modulation of skeletal muscles.2017
Author(s)
Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 12902-12902
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.2015
Author(s)
Suan D, Nguyen A, Moran I, Bourne K, Hermes JR, Arshi M, Hampton HR, Tomura M, Miwa Y, Kelleher AD, Kaplan W, Deenick EK, Tangye SG, Brink R, Chtanova T, Phan TG.
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Journal Title
Immunity
Volume: 42
Issue: 4
Pages: 704-718
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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