| Project/Area Number |
15K08157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齋野 朝幸 岩手医科大学, 医学部, 教授 (40305991)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細静脈 / 細動脈 / 血管平滑筋 / 細胞内カルシウム変動 / 電子顕微鏡 / STEM連続切片 / 立体構築 / セロトニン / アンギオテンシン / ノルアドレナリン / アデノシン３リン酸 / アデノシン3リン酸 |
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| Outline of Final Research Achievements |
Very few data has been available on physiololical characters of smooth muscle cessl (SMC) of vein/venule. Intracellular Ca2+ concentration ([Ca2+]i) plays an essential role in stimulus-response coupling in a great variety of tissue/cells, including vascular SMC. We observed [Ca2+]i dynamics of SMC of intact venules to clarify which transmitters can elicit any response of venules, and compered with those of SMC of arterioles. SMC of arterioles are fusiform in shape, while those of venules are polygonal. 5-Hydroxytryptamine (5-HT), ATP, NorAdr, and angiotensin II elicited an increase in [Ca2+]i in most SMC of arterioles. On the contrary, the[Ca2+]i increase in SMC of venules during 5-HT or ATP stimulation was faint, but NorAd and Angiotensin II can induce an evident increase in SMC. This may mean the reduction of vascular volume of venous system can play a pivotal role in increase of systemic blood pressure.
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