| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Our resukts disclosed that amyloid deposition in islets were markedly accerelated in the subjects of type 2 diabetic subjects complicated with macrovascular disease (vT2DM) and elderly onset T2DM. Since these amyloid depositions did not correlate with BMI, the mechanism assumed to be different from that in BMI. In vT2DM, the alterations of vascular architecture in the islets (reduction of intra-islet vascular area, increase in vascular density of surrounding islets and thickness of vascular wall in the islets) were observed, suggesting the possible promotion of amyloid deposition in the islets.Intraductal epithelial neoplasm was frequently onserved in elderly onset T2DM. This and islet amyloid deposition may synergistically accerelate the atrophy of pancreas in elderly onset T2DM.
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