2017 Fiscal Year Final Research Report
Exploration of new therapy for type 2 diabetes regulating epigenetic state evoked by islet amyloid deposition
Project/Area Number |
15K09374
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Hirosaki University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 2型糖尿病 / β細胞容積 / 膵島アミロイド沈着 / 大血管障害 / 老人発症糖尿病 / β細胞減少 |
Outline of Final Research Achievements |
Our resukts disclosed that amyloid deposition in islets were markedly accerelated in the subjects of type 2 diabetic subjects complicated with macrovascular disease (vT2DM) and elderly onset T2DM. Since these amyloid depositions did not correlate with BMI, the mechanism assumed to be different from that in BMI. In vT2DM, the alterations of vascular architecture in the islets (reduction of intra-islet vascular area, increase in vascular density of surrounding islets and thickness of vascular wall in the islets) were observed, suggesting the possible promotion of amyloid deposition in the islets.Intraductal epithelial neoplasm was frequently onserved in elderly onset T2DM. This and islet amyloid deposition may synergistically accerelate the atrophy of pancreas in elderly onset T2DM.
|
Free Research Field |
2型糖尿病膵島病理学的研究
|