Exploration of new therapy for type 2 diabetes regulating epigenetic state evoked by islet amyloid deposition
Project/Area Number |
15K09374
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Hirosaki University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 2型糖尿病 / β細胞容積 / 膵島アミロイド沈着 / 大血管障害 / 老人発症糖尿病 / β細胞減少 / 膵島アミロイド / β細胞 / アミロイド / 急性心筋梗塞 / 2型糖尿病 / 動脈硬化 |
Outline of Final Research Achievements |
Our resukts disclosed that amyloid deposition in islets were markedly accerelated in the subjects of type 2 diabetic subjects complicated with macrovascular disease (vT2DM) and elderly onset T2DM. Since these amyloid depositions did not correlate with BMI, the mechanism assumed to be different from that in BMI. In vT2DM, the alterations of vascular architecture in the islets (reduction of intra-islet vascular area, increase in vascular density of surrounding islets and thickness of vascular wall in the islets) were observed, suggesting the possible promotion of amyloid deposition in the islets.Intraductal epithelial neoplasm was frequently onserved in elderly onset T2DM. This and islet amyloid deposition may synergistically accerelate the atrophy of pancreas in elderly onset T2DM.
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Report
(4 results)
Research Products
(15 results)