| Project/Area Number |
15K09955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
SHIMOSEGAWA EKU 大阪大学, 医学系研究科, 寄附講座教授 (30370258)
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| Co-Investigator(Kenkyū-buntansha) |
池田 隼人 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (30649083)
金井 泰和 大阪大学, 医学系研究科, 寄附講座助教 (60397643)
畑澤 順 大阪大学, 医学系研究科, 教授 (70198745)
渡部 直史 大阪大学, 医学系研究科, 助教 (90648932)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | アスタチン-211 / At-211 / 甲状腺摂取率 / α線 / アルファ線 / 甲状腺癌 / 内用療法 / 核医学治療 / I-123 / アスタチン / 胃摂取率 / 甲状腺 |
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| Outline of Final Research Achievements |
The present study evaluated the distribution of At-211 by a daughter nuclide Po-211 imaging with gamma camera in normal rats, and revealed the physiological accumulation of At-211 of the thyroid gland and the stomach. We estimated thyroid and stomach uptake ratio of At-211 with comparing the difference between intravenous administration and oral intake. In addition, we evaluated At-211 accumulation in mice model of the thyroid cancer cell expressing the human Na/I symporter.
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