| Project/Area Number |
15K09969
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Nakai Motoki 和歌山県立医科大学, 医学部, 准教授 (30464671)
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| Co-Investigator(Kenkyū-buntansha) |
生駒 顕 和歌山県立医科大学, 医学部, 講師 (60458065)
上硲 敦文 和歌山県立医科大学, 医学部, 助教 (30750913)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | NBCA / エタノール / NLE / EVAR / エンドリーク / ステントグラフト / 予防的動脈瘤塞栓術 / リピオドール / 腹部大動脈瘤 / 瘤内塞栓 / ＮLE |
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| Outline of Final Research Achievements |
NLE is a less adhesive embolic material than NBCA. In six swine, after creating abdominal aortic aneurysm (AAA), stent-graft was inserted, and type II endoleak model was created, and then intraoperative aneurysmal sac embolization using NLE was performed. The purpose of this study was to evaluate the feasibility and efficacy of intraoperative aneurysmal sac embolization during EVAR using NLE for type II endoleak in swine. As control group, EVAR without sac embolization was performed in two swine. In four swine, AAA sac was embolized using NLE immediately after EVAR (NLE embolization group). Aortography was performed immediately and three days after the procedure, and then the aneurysms were extracted and HE staining was performed. In NLE embolization group, endoleak disappeared three days after the procedure and AAA sac was occupied with thrombus and embolic material, and inflammatory changes were recognized in aneurysmal sac wall.
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| Academic Significance and Societal Importance of the Research Achievements |
豚腹部大動脈瘤のType IIエンドリークモデルを作製し、我々が考案したNLE(NBCA-lipiodol-ethanol液)で瘤内の塞栓術を行い、その有効性及び安全性を確認した。作製した腹部大動脈瘤にステントグラフト内挿術を行い、同時にNLEを動脈瘤内に注入・充填することにより、分枝血管からの動脈瘤内への血流を遮断し、Type IIエンドリークの発生を防止することができた。すなわち、実臨床においてNLEを用いた予防的動脈瘤塞栓術は、ステントグラフト内挿術後のエンドリークの発生及び瘤径拡大を抑制でき、ステントグラフト内挿術の治療成績の向上につながると期待できる。
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