Comprehensive analysis to elucidate the mechanism of cancer metabolism in esophageal squamous cell carcinoma
| Project/Area Number |
15K10122
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Japanese Foundation for Cancer Research |
|---|
Principal Investigator |
Watanabe Masayuki 公益財団法人がん研究会, 有明病院 消化器外科, 部長 (80254639)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
森 誠一 公益財団法人がん研究会, がんプレシジョン医療研究センター 次世代がん研究シーズ育成プロジェクト, プロジェクトリーダー (10334814)
馬場 祥史 熊本大学, 医学部附属病院, 特任講師 (20599708)
澤山 浩 熊本大学, 医学部附属病院, 非常勤診療医師 (40594875)
今村 裕 公益財団法人がん研究会, 有明病院 消化器外科, 副医長 (70583045)
|
|---|
| Research Collaborator |
Haraguchi Ikumi 公益財団法人がん研究会, がんプレシジョン医療研究センター がんモデル開発グループ, 特任研究助手
Ogata Yoko 熊本大学, 大学院生命科学研究部 消化器外科学, 技術補佐員
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 食道癌 / 代謝 / 脂肪 / 肥満 / 食道扁平上皮癌 / がん代謝 / 内臓脂肪 / 糖尿病 / microRNA / サイトカイン |
|---|
| Outline of Final Research Achievements |
In this study, we have collected omental fat, extracting total RNA, and then submitted those to microarray analysis [high-BMI cases (BMI more than 25, N=3) vs. normal-BMI cases (BMI around 20, N=3)], in the patient with esophageal squamous cell carcinoma who underwernt curative resection in our institution. Pathway analysis revealed that complementary activation pathway was significantly upregulated in the high-BMI cases (N=3), compared to the normal-BMI cases (P=0.0028). Especially, we observed significantly overexpression of C3 and C4 genes in the high-BMI cases. Our results suggest that in obese patients with esophageal squamous cell carcinoma, complements C3/C4 were highly produced in omental fat, activate classical pathyway of complement at the tumor microenvironments.
|
Report
(4 results)
Research Products
(19 results)
-
-
[Journal Article] Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc.2017
Author(s)
Izumi D, Ishimoto T, Miyake K, Eto T, Arima K, Kiyozumi Y, Uchihara T, Kurashige J, Iwatsuki M, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Goel A, Tan P, Baba H.
-
Journal Title
Stem Cells.
Volume: 35(9)
Issue: 9
Pages: 2027-2036
DOI
Related Report
Peer Reviewed
-
[Journal Article] Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.2017
Author(s)
Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Lin SJ, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P.
-
Journal Title
Gastroenterology
Volume: 153
Pages: 191-204
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
[Journal Article] Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer2016
Author(s)
Kosumi K, Baba Y, Sakamoto Y, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H
-
Journal Title
Int J Cancer
Volume: 138
Issue: 2
Pages: 428-39
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Tumor/normal esophagus ratio in 18f-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma2016
Author(s)
Izumi D, Yoshida N, Watanabe M, Shiraishi S, Ishimoto T, Kosumi K, Tokunaga R, Taki K, Higashi T, Harada K, Miyata T, Ida S, Imamura Y, Iwagami S, Baba Y, Miyamoto Y, Sakamoto Y, Yamashita Y, Baba H
-
Journal Title
J Gastroenterol
Volume: 未定
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
