| Project/Area Number |
15K10122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Watanabe Masayuki 公益財団法人がん研究会, 有明病院 消化器外科, 部長 (80254639)
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| Co-Investigator(Kenkyū-buntansha) |
森 誠一 公益財団法人がん研究会, がんプレシジョン医療研究センター 次世代がん研究シーズ育成プロジェクト, プロジェクトリーダー (10334814)
馬場 祥史 熊本大学, 医学部附属病院, 特任講師 (20599708)
澤山 浩 熊本大学, 医学部附属病院, 非常勤診療医師 (40594875)
今村 裕 公益財団法人がん研究会, 有明病院 消化器外科, 副医長 (70583045)
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| Research Collaborator |
Haraguchi Ikumi 公益財団法人がん研究会, がんプレシジョン医療研究センター がんモデル開発グループ, 特任研究助手
Ogata Yoko 熊本大学, 大学院生命科学研究部 消化器外科学, 技術補佐員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 食道癌 / 代謝 / 脂肪 / 肥満 / 食道扁平上皮癌 / がん代謝 / 内臓脂肪 / 糖尿病 / microRNA / サイトカイン |
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| Outline of Final Research Achievements |
In this study, we have collected omental fat, extracting total RNA, and then submitted those to microarray analysis [high-BMI cases (BMI more than 25, N=3) vs. normal-BMI cases (BMI around 20, N=3)], in the patient with esophageal squamous cell carcinoma who underwernt curative resection in our institution. Pathway analysis revealed that complementary activation pathway was significantly upregulated in the high-BMI cases (N=3), compared to the normal-BMI cases (P=0.0028). Especially, we observed significantly overexpression of C3 and C4 genes in the high-BMI cases. Our results suggest that in obese patients with esophageal squamous cell carcinoma, complements C3/C4 were highly produced in omental fat, activate classical pathyway of complement at the tumor microenvironments.
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