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Regulation of articular joint diseases by transcription factor family C/EBP

Research Project

Project/Area Number 15K10462
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Morizaki Yutaka  東京大学, 医学部附属病院, 助教 (30508099)

Co-Investigator(Kenkyū-buntansha) 田中 健之  東京大学, 医学部附属病院, 助教 (00583121)
矢野 文子  東京大学, 医学部附属病院, 特任講師 (80529040)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords整形外科学 / 変形性関節症
Outline of Final Research Achievements

CCAAT/enhancer-binding protein (C/EBP) beta regulates chondrocyte differentiaion and proliferation during endochondral ossification. In the present study, we examined expression and function of other C/EBP family members in chondrocytes. Among
four members with transactivation domain, expression of Cebpb and Cebpd was abundant compared to Cebpa. C/EBPs suppressed expressions of early differentiation
markers including Col2a1, aggrecan and Sox9, enhanced those of late differentiation markers including Mmp13, Vegfa and Col10a1, and decelerated cell proliferation, indicating their overlapped functions in chondrocytes. In contrast, A-CEBP, which exerts a dominant-negative effect against all C/EBPs, increased expressions of early differentiation markers and decreased those of late differentiation markers.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 Other

All Journal Article (12 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (3 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.2017

    • Author(s)
      Taniguchi Y, Kawata M, Chang SH, Mori D, Okada K, Kobayashi H, Sugita S, Hosaka Y, Inui H, Taketomi S, Yano F, Ikeda T, Akiyama H, Mills AA, Chung UI, Tanaka S, Kawaguchi H, and Saito T*
    • Journal Title

      Arthritis Rheumatol.

      Volume: 69 Issue: 3 Pages: 598-609

    • DOI

      10.1002/art.39976

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Different regulation of limb development by p63 transcript variants2017

    • Author(s)
      Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung UI, Shimogori T, Mills AA, Tanaka S, Saito T
    • Journal Title

      PLoS One

      Volume: 12 Issue: 3 Pages: e0174122-e0174122

    • DOI

      10.1371/journal.pone.0174122

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sandwich-type PLLA-nanosheets loaded with BMP-2 induce bone regeneration in critical-sized mouse calvarial defects2017

    • Author(s)
      Huang KC, Yano F, Murahashi Y, Takano S, Kitaura Y, Chang SH, Soma K, Ueng SWN, Tanaka S, Ishihara K, Okamura Y, Moro T, Saito T
    • Journal Title

      Acta Biomater

      Volume: 59 Pages: 12-20

    • DOI

      10.1016/j.actbio.2017.06.041

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Mouse Intervertebral Disc Degeneration Model by Surgically-Induced Instability2017

    • Author(s)
      Oichi T, Taniguchi Y, Soma K, Chang SH, Yano F, Tanaka S, Saito T
    • Journal Title

      Spine

      Volume: ― Issue: 10 Pages: 1-1

    • DOI

      10.1097/brs.0000000000002427

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Grey-scale sonography and sonoelastography for diagnosing carpal tunnel syndrome.2016

    • Author(s)
      Miyamoto H, Morizaki Y, Kashiyama T, Tanaka S.
    • Journal Title

      World J Radiol.

      Volume: 8 Issue: 3 Pages: 281-7

    • DOI

      10.4329/wjr.v8.i3.281

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study.2016

    • Author(s)
      Kodama R, Muraki S, Oka H, Iidaka T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Morizaki Y, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshimura N.
    • Journal Title

      Mod Rheumatol

      Volume: 26 Issue: 5 Pages: 767-773

    • DOI

      10.3109/14397595.2015.1130673

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes.2016

    • Author(s)
      Kobayashi H, Chang S, Mori D, Itoh S, Hirata M, Hosaka Y, Taniguchi Y, Okada K, Mori Y, Yano F, Chung U, Akiyama H, Kawaguchi H, Tanaka S, Saito T.
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 13336-13336

    • DOI

      10.1038/ncomms13336

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability2016

    • Author(s)
      Chang SH, Yasui T, Taketomi S, Matsumoto T, Kim-Kaneyama JR, Omiya T, Hosaka Y, Inui H, Omata Y, Yamagami R, Mori D, Yano F, Chung U, Tanaka S, Saito T.
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 24 Issue: 4 Pages: 688

    • DOI

      10.1016/j.joca.2015.11.008

    • URL

      https://localhost/en/publications/8df5380e-9063-4943-8ae2-cc22da55f2e9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study.2016

    • Author(s)
      Kodama R, Muraki S, Oka H, Iidaka T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Morizaki Y, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshimura N.
    • Journal Title

      Mod Rheumatol.

      Volume: not yet

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] <b>Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem </b><b>cells </b>2015

    • Author(s)
      Saito T, Yano F, Mori D, Kawata M, Hoshi K, Takato T, Masaki H, Otsu M, Eto K, Nakauchi H, Chung UI, Tanaka S
    • Journal Title

      Biomedical Research

      Volume: 36 Issue: 3 Pages: 179-186

    • DOI

      10.2220/biomedres.36.179

    • NAID

      130005083858

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/22015

    • Author(s)
      Saito T, Ohba S, Yano F, Seto I, Yonehara Y, Takato T, Ogasawara T
    • Journal Title

      Cell Reprogram

      Volume: 17 Issue: 3 Pages: 227-234

    • DOI

      10.1089/cell.2014.0059

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] <b>Regulation of mouse chondrocyte differentiation by CCAAT/enhancer-binding pr</b><b>oteins </b>2015

    • Author(s)
      Okuma T, Hirata M, Yano F, Mori D, Kawaguchi H, Chung UI, Tanaka S, Saito T
    • Journal Title

      Biomedical Research

      Volume: 36 Issue: 1 Pages: 21-29

    • DOI

      10.2220/biomedres.36.21

    • NAID

      130004903876

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Runx1による軟骨分化制御機構2016

    • Author(s)
      矢野文子、ほか
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Runx1による軟骨分化制御機構2016

    • Author(s)
      矢野文子、ほか
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Runx1による軟骨分化制御機構2015

    • Author(s)
      矢野文子、他
    • Organizer
      第16回運動器科学研究会
    • Place of Presentation
      南日本新聞 みなみホール(鹿児島県・鹿児島市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京大学医学部整形外科

    • URL

      http://www.u-tokyo-ortho.jp/

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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