Elucidation of the role of inflammation and apoptosis and development of a new target in age-related macular degeneration
| Project/Area Number |
15K10875
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Hirano Yoshio 名古屋市立大学, 大学院医学研究科, 講師 (40405163)
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| Co-Investigator(Kenkyū-buntansha) |
野崎 実穂 名古屋市立大学, 大学院医学研究科, 講師 (00295601)
安川 力 名古屋市立大学, 大学院医学研究科, 准教授 (00324632)
小椋 祐一郎 名古屋市立大学, 大学院医学研究科, 教授 (70191963)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脈絡膜新生血管 / 炎症 / アポトーシス / 網膜色素上皮 / 加齢黄斑変性 |
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| Outline of Final Research Achievements |
Age-related macular degeneration (AMD) is a vision-threatening disease and the number of patients continues to grow. Recently developed anti-vascular endothelial growth factor (VEGF) therapy for choroidal neovascularization (CNV) has revolutionized the treatment in visual improvement. However, there are still ineffective cases or most of the patients need multiple injections of anti-VEGF agents. We aimed to elucidate the pathophysiology of CNV using mouse laser CNV model to investigate a new target for CNV. Inflammation and apoptosis were associated with the CNV formation. Therefore, to control inflammation and apoptosis chould be an alternative therapy to suppress vision loss associated with CNV in AMD.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Intravenous immune globulin suppresses angiogenesis in mice and humans.2016
Author(s)
Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, erur N, Li S, Yasuma T, Fowler BJ, Wringht CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Bastos-Carvalho A, De Falco S, Ambati J
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Journal Title
Signal Transduct Target Ther
Volume: 1
Pages: 15002-15002
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Human IgG1 antibodies suppress angiogenesis in a target-independent manner.2016
Author(s)
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JHW, et al.
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Journal Title
Signal Transduct Target Ther
Volume: 1
Pages: 15001-15001
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intravitreous immune globulin suppresses angiogenesis in mice and humans.2016
Author(s)
Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, Kerur N, Li S, Yasuma T, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Bastos-Carvalho A, De Falco S, Ambati J.
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Journal Title
Signal Transduct Target Ther
Volume: 1
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Human IgG1 antibodies suppress angiogenesis in a target-independent manner.2016
Author(s)
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, et al.
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Journal Title
Signal Transduct Target Ther
Volume: 1
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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