| Project/Area Number |
15K11312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田村 佳代 京都大学, 医学(系)研究科(研究院), その他 (20378714)
中尾 一祐 京都大学, 医学研究科, 助教 (40599932)
山口 昭彦 京都大学, 医学研究科, 講師 (50423942)
園部 純也 京都大学, 医学研究科, 講師 (50464219)
別所 和久 京都大学, 医学研究科, 教授 (90229138)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | LYDEX |
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| Outline of Final Research Achievements |
LYDEX has an effect for the in vivo site which does not move. LYDEX has biocompatibility, antibacterial action and effects to adhere to the tissue.Also, we can mix with cytokine such as FGF-2.Because it gradually disintegrates itself, it is the ideal biomaterial as the Drug Delivery System (DDS) effects. However, in this animal experiment, in a extraction site of tooth, tissue adhesive property goes out when it is used area of existing saliva or existing blood.Also, a problem to collapse at chewing became clear because it was fragile with an agar form. LYDEX was not suitable for intraoral application after extracting a tooth in this study, but seemed to be useful for the clinical application such as the osteosynthesis by DDS effects in the tissue.
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