Project/Area Number |
15K15241
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Sakai Toshiyuki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20186993)
|
Co-Investigator(Kenkyū-buntansha) |
TOMOSUGI Mano (HORINAKA Mano) 京都府立医科大学, 医学研究科, 講師 (80512037)
|
Project Period (FY) |
2015-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
Keywords | がん / 予防 / 喫煙 / がん細胞死 / TRAIL / 分子予防 / タバコ成分 / 免疫 / アポトーシス |
Outline of Final Research Achievements |
TRAIL is a cytokine which can induce apoptosis against cancer cells and contribute to cancer prevention. We examined the effects of cigarette nicotine for "the TRAIL pathway". At first, we investigated the influence of the nicotine on the ability of TRAIL production in the human immune cells. As the results, nicotine did not suppress or induce the TRAIL expression in various kinds of conditions. In addition, we investigated the influence of the nicotine on cell proliferation and the expressions of anti-apoptotic molecules XIAP and survivin using human bladder cancer cells. As the results, nicotine did not suppress or enhance the cell proliferation, and the expressions of XIAP and survivin in various kinds of conditions.
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