2015 Fiscal Year Final Research Report
Elucidation of the novel mechanisms of carcinogenesis induced by the cigarette and development of cancer prevention for carcinogenesis by sidestream smoke
Project/Area Number |
15K15241
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Sakai Toshiyuki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20186993)
|
Co-Investigator(Kenkyū-buntansha) |
TOMOSUGI Mano (HORINAKA Mano) 京都府立医科大学, 医学研究科, 講師 (80512037)
|
Project Period (FY) |
2015-04-01 – 2016-03-31
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Keywords | がん / 予防 / 喫煙 / がん細胞死 / TRAIL |
Outline of Final Research Achievements |
TRAIL is a cytokine which can induce apoptosis against cancer cells and contribute to cancer prevention. We examined the effects of cigarette nicotine for "the TRAIL pathway". At first, we investigated the influence of the nicotine on the ability of TRAIL production in the human immune cells. As the results, nicotine did not suppress or induce the TRAIL expression in various kinds of conditions. In addition, we investigated the influence of the nicotine on cell proliferation and the expressions of anti-apoptotic molecules XIAP and survivin using human bladder cancer cells. As the results, nicotine did not suppress or enhance the cell proliferation, and the expressions of XIAP and survivin in various kinds of conditions.
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Free Research Field |
がん予防
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