| Project/Area Number |
15K15712
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Nagoya City University |
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Principal Investigator |
Michikawa Makoto 名古屋市立大学, 大学院医学研究科, 教授 (40270912)
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| Co-Investigator(Kenkyū-buntansha) |
赤川 安正 奥羽大学, 歯学部, 教授 (00127599)
大上 博史 広島大学, 医歯薬保健学研究科(歯), 助教 (70711307)
小野 卓史 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30221857)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 認知症 / 歯牙欠損 / 咀嚼機能低下 / BDNF / 認知機能 / 歯科疾患 / 鼻閉 / 抜歯 / 粉末食 / 認知機能障害 / 神経細胞死 |
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| Outline of Final Research Achievements |
The relationship between teeth loss or mastication dysfunction and dementia including Alzheimer’s disease has been reported. However, the molecular mechanism underlying these remain unknown. In this study we have examined teeth loss-induced and mastication dysfunction-induced memory impairment using mice and identified the mechanisms.
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