Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
Drug induced lung injury is a severe adverse event in the respiratory tract, and more than 1000 cases are reported annually by the regulation of the Pharmaceutical Affairs Law. Therefore, in this study, metabolomics analysis was performed using mouse model of drug induced lung injury, and the characteristic of drug induced lung injury in metabolite alteration was clarified. Significant alterations of lipid molecules were observed in lung and bronchoalveolar lavage fluids, suggesting that these molecules are involved in the development of drug induced lung injury.
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