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Metabolomics approach for understanding the underlying mechanism of durg induced lung injury

Research Project

Project/Area Number 15K19169
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionNational Institute of Health Sciences

Principal Investigator

Saito Kosuke  国立医薬品食品衛生研究所, 医薬安全科学部, 室長 (10650608)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMetabolomics / lung injury / リピドミクス / 薬剤性間質性肺炎 / メタボロミクス
Outline of Final Research Achievements

Drug induced lung injury is a severe adverse event in the respiratory tract, and more than 1000 cases are reported annually by the regulation of the Pharmaceutical Affairs Law. Therefore, in this study, metabolomics analysis was performed using mouse model of drug induced lung injury, and the characteristic of drug induced lung injury in metabolite alteration was clarified. Significant alterations of lipid molecules were observed in lung and bronchoalveolar lavage fluids, suggesting that these molecules are involved in the development of drug induced lung injury.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2018

All Presentation (1 results) (of which Invited: 1 results)

  • [Presentation] Lipid profiling as a tool for understanding mechanisms of drug induced toxicity2018

    • Author(s)
      Kosuke Saito
    • Organizer
      2018 International Meeting on 22nd MDO and 33rd JSSX
    • Related Report
      2017 Annual Research Report
    • Invited

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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