Metabolomics approach for understanding the underlying mechanism of durg induced lung injury

Research Project

Project/Area Number	15K19169
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Applied pharmacology
Research Institution	National Institute of Health Sciences
Principal Investigator	Saito Kosuke 国立医薬品食品衛生研究所, 医薬安全科学部, 室長 (10650608)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	Metabolomics / lung injury / リピドミクス / 薬剤性間質性肺炎 / メタボロミクス
Outline of Final Research Achievements	Drug induced lung injury is a severe adverse event in the respiratory tract, and more than 1000 cases are reported annually by the regulation of the Pharmaceutical Affairs Law. Therefore, in this study, metabolomics analysis was performed using mouse model of drug induced lung injury, and the characteristic of drug induced lung injury in metabolite alteration was clarified. Significant alterations of lipid molecules were observed in lung and bronchoalveolar lavage fluids, suggesting that these molecules are involved in the development of drug induced lung injury.

Report

(4 results)