association between activity of daily living and tau deposition in alzheimers disease

• Project/Area Number: 16H06621
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Basic / Social brain science
• Research Institution: Tohoku University
• Principal Investigator: Harada Aiko 東北大学, 大学病院, 助教 (30778634)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アルツハイマー病 / 日常生活動作 / タウ / PET / 認知症 / 脳・神経 / 老年医学 / 診断

Outline of Final Research Achievements

Tau accumulation in the brain correlates with the cognitive function in Alzheimer’s disease (AD). The activity of daily living (ADL) which determines the stage of dementia is also seemed to correlate with tau deposition. On order to verify the hypothesis, we performed longitudinal [18F]THK-5351 PET scan which have been developed as tau PET tracer and ADL score in AD and mild cognitive impairment patients. At baseline study, [18F]THK-5351 retention significantly correlated with the ADL score. However, the facts that [18F]THK-5351 bound to monoamine oxidase-B (MAO-B) and might have limited utility as a biomarker of tau protein were revealed in other post-mortem study . In consequence, prearranged follow up study was cancelled.

Research Products

• [Journal Article] [18F]-THK5351 PET correlates with topology and symptom severity in progressive supranuclear palsy. (2018)
  • Author(s): Brendel M, Schoneckerr S, Hoglinger G, Lindner S, Havla J, Blautzik J, Sauerbeck J, Rohrer G, Zach C, Vettermann F, Lang AE, Golbe L, Nubling G, Bartenstein P, Furukawa K, Ishiki A, Botzel K, Danek A, Okamura N, Levin J, Rominger A.
  • Journal Title: Front Aging Neurosci. Volume: 9 Pages: 440-440
  • DOI: 10.3389/fnagi.2017.00440
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlations of (18)F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease. (2018)
  • Author(s): Harada R, Furukawa K, et al.
  • Journal Title: J Nucl Med Volume: 59 Issue: 4 Pages: 671-674
  • DOI: 10.2967/jnumed.117.197426
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tau imaging with [18F]THK-5351 in progressive supranuclear palsy. (2017)
  • Author(s): Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
  • Journal Title: Eur J Neurol. Volume: 24 Issue: 1 Pages: 130-136
  • DOI: 10.1111/ene.13164
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Erratum to: Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351. (2017)
  • Author(s): Harada R, Furumoto S, Tago T, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y, Okamura N.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 44 Pages: 177-177
  • Peer Reviewed
• [Presentation] [18F]THK-5351 accumulation in patients with Alzheimer’s disease. (2017)
  • Author(s): Aiko Ishiki, Katsutoshi Furukawa, Naoki Tomita, Ryuichi Harada, Nobuyuki Okamura, Yukitsuka Kudo, Hiroyuki Arai
  • Organizer: Alzheimer’s Association International Conference 2017
  • Int'l Joint Research
• [Presentation] アルツハイマー病患者における[18F]THK-5351集積の経時的変化 (2017)
  • Author(s): 石木愛子, 冨田尚希, 冲永壯治, 岡村信行, 古川勝敏, 荒井啓行
  • Organizer: 第36回日本認知症学会学術集会