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Development of an innovative method to modify life style using a dietary pattern score

Research Project

Project/Area Number 16K09785
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionThe University of Tokushima

Principal Investigator

FUNAKI Makoto  徳島大学, 病院, 特任教授 (10467821)

Co-Investigator(Kenkyū-buntansha) 秦 明子  徳島大学, 病院, 特任助教 (20570948)
米本 孝二  琉球大学, 医学部, 教授 (90398090)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsメタボリックシンドローム / 食事パターン / 食事パターンスコア / メタボリック症候群
Outline of Final Research Achievements

Appropriate diet is indispensable to prevent an onset of metabolic syndrome. Intensive studies have been made to reveal the type of food favorable/unfavorable to develop metabolic syndrome. However, meals are composed of multiple types of foods and avoiding/choosing certain types of foods will affect the intake of other types of foods, as well. Therefore, to determine if some diets are favorable/unfavorable to an onset of metabolic syndrome, it is crucial to elucidate a dietary pattern associated with an onset of metabolic syndrome and establish a method to evaluate how close/distant a certain meal is to/from such a dietary pattern. In this study, we succeeded in establishing a dietary pattern, which is associated with an onset of metabolic syndrome, and made a formula to score the distance between certain dietary patterns and the one associated with developing metabolic syndrome. This score will enable to assess the risk of developing metabolic syndrome from a dietary pattern.

Academic Significance and Societal Importance of the Research Achievements

毎日の食事がメタボ発症に近づくものか、或いは発症を遠ざけるものであるか、についてその食事のスコアを見ることで容易に判定することが可能になる。したがって食事内容を入力するとスコアが表示されるアプリなどのシステムを作成することにより、メタボ対策に不可欠である適正な食事内容を取るための実践的な指導を容易に行うことが可能になり、患者数の増加が社会的な問題となっているメタボ対策に貢献できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (15 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Association of accumulated advanced glycation end products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes.2019

    • Author(s)
      Mori H, Kuroda A, Ishizu M, Ohishi M, Takashi Y, Otsuka Y, Taniguchi S, Tamaki M, Kurahashi K, Yoshida S, Endo I, Aihara KI, Funaki M, Akehi Y, Matsuhisa M.
    • Journal Title

      J Diabetes Investig.

      Volume: Jan 24 Pages: 1-9

    • NAID

      120006768443

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma.2018

    • Author(s)
      Nakamoto M, Shuto E, Nakamoto A, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minagawa T, Tamura A, Kuwamura Y, Funaki M, Sakai T.
    • Journal Title

      Asia Pac J Clin Nutr.

      Volume: 27 Pages: 1277-1285

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers2018

    • Author(s)
      Yang X, Nakamoto M, Shuto E, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minamigawa T, Kuwamura Y, Tamura A, Uemura H, Arisawa K, Funaki M, Sakai T
    • Journal Title

      J Med Invest

      Volume: 65 Pages: 74-80

    • NAID

      130006575620

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential Role of Free Fatty Acids in the Pathogenesis of Periodontitis and Primary Sjogren’s Syndrome2017

    • Author(s)
      Shikama Y, Kudo Y, Ishimaru N, Funaki M.
    • Journal Title

      Int J Mol Sci

      Volume: 18 Issue: 4 Pages: 1-8

    • DOI

      10.3390/ijms18040836

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 徳島県における血中アディポネクチンとPrediabetes発症との関連2018

    • Author(s)
      秦明子、安藝菜奈子、三好雅士、中尾隆之、市原多香子、田村綾子、南川貴子、桑村由美、船木真理
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体環境に類似した肝細胞培養システムを利用した非アルコール性脂肪肝炎のin vitroモデルの作成2018

    • Author(s)
      森島真幸、堀川一樹、船木真理
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生活習慣病患者の尿中酸化ストレス指標における糖尿病および薬物療法の影響2018

    • Author(s)
      粟飯原賢一、上元良子、石川カズ江、森本佳奈、桝田志保、山上紘規、山口佑樹、原倫代、細井美希、倉橋清衛、吉田守美子、乙田敏城、湯浅智之、黒田暁生、明比祐子、遠藤逸朗、船木真理、福本誠二、松久宗英、東博之、安倍正博
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] かかりつけ患者に対するSGLT2阻害薬の投与開始タイミングの特徴と、投与開始後の体重・eGFR・ALT・脂質代謝の変化2018

    • Author(s)
      田蒔基行、高士祐一、乙田敏城、福本誠二、黒田暁生、明比祐子、森博康、谷口諭、鈴木麗子、山田美鈴、石津将、大石真実、白神敦久、粟飯原賢一、船木 真理、松久宗英
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Serum Total Adiponectin Level is Associated with Incident Prediabetes in Japanese Workers2018

    • Author(s)
      Akiko Hata, Masashi Miyoshi, Takayuki Nakao, Takako Ichihara, Ayako Tamura, Takako Minagawa, Yumi Kuwamura, Makoto Funaki
    • Organizer
      第78回米国糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum total adiponectin level and new onset of prediabetes in Japanese workers: Tokushima Cohort Study2018

    • Author(s)
      Akiko Hata, Masashi Miyoshi, Takayuki Nakao, Takako Ichihara, Ayako Tamura, Takako Minagawa, Yumi Kuwamura, Makoto Funaki
    • Organizer
      12th IDF-WPR Congress 2018 & 10th AASD Scientific Meeting (IDF-WPR 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メカノバイオロジーをヒトの病気治療に活用する2017

    • Author(s)
      船木真理
    • Organizer
      第5回 日本バイオマテリアル学会 中四国シンポジウム
    • Place of Presentation
      徳島大学
    • Year and Date
      2017-01-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 血中AIMとメタボリックシンドローム発症に関する疫学的検討2017

    • Author(s)
      秦明子、安藝菜奈子、三好雅士、中尾隆之、田村綾子、市原多香子、南川貴子、桑村由美、船木真理
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尿中アディポネクチンの腎障害予測マーカーに関する研究2017

    • Author(s)
      藤本侑希、渡辺敏弘、森本彩、熊本はな、須藤浩三、吉田智一、森博康、松久宗英、秦明子、船木真理、山本真弓、橋田誠一
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尿中アディポネクチンの腎障害予測マーカーに関する検討2017

    • Author(s)
      藤本侑希、渡辺敏弘、森博康、秦明子、山本真弓、橋田誠一
    • Organizer
      第64回日本栄養改善学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尿中アディポネクチンの腎障害指標に関する研究2017

    • Author(s)
      藤本侑希、渡辺敏弘、森博康、秦明子、山本真弓、橋田誠一
    • Organizer
      第57回日本臨床化学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Serum Apoptosis Inhibitor of Macrophage is Related to Development of Metabolic Syndrome in Japanese Male Workers2017

    • Author(s)
      Akiko Hata, Koji Yonemoto, Nanako Aki, Masashi Miyoshi, Takayuki Nakao, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Makoto Funaki
    • Organizer
      第77回米国糖尿病学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Potential Application of Mesenchymal Stem Cells to Suppress Autoimmunity in Type 1 Diabetes2016

    • Author(s)
      Makoto Funaki, Kaori Abe
    • Organizer
      American Diabetes Association, 76th Scientific Sessions
    • Place of Presentation
      ニューオーリンズ(アメリカ合衆国)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 徳島県における食事パターンとメタボリックシンドロームとの関連2016

    • Author(s)
      秦 明子、米本 孝二、安藝 菜奈子、酒井 徹、首藤 恵泉、中尾 隆之、三好 雅士、船木 真理
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      みやこメッセ(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 休眠状態の間葉系幹細胞が持つ免疫抑制能による一型糖尿病治療の可能性2016

    • Author(s)
      阿部佳織、船木真理
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      みやこメッセ(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Book] BIOLOGY AND ENGINEERING OF STEM CELL NICHES2017

    • Author(s)
      A SI Ahmed, P Anversa, F Apoorva, CK Arakawa, DJ Baylink, L Benameur, J Bernhard, MB M Blatchley, JT Borenstein, N Brandenberg, DT Breault, CE Brun, RL Carrier, NM Cetinbas, W Chen, YH Cheng, FP Chevalier, PA Janmey, M Funaki, 等
    • Total Pages
      644
    • Publisher
      ELSEVIER
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] AIMを指標とするメタボリック・シンドロームの発症予測方法2018

    • Inventor(s)
      秦 明子、船木 真理
    • Industrial Property Rights Holder
      秦 明子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 運体力格差変化、医療検査値格差変化、及びアディポネクチン値変化提示を行う運動メニュー提示支援システム、及び方法2018

    • Inventor(s)
      船木 真理
    • Industrial Property Rights Holder
      船木 真理、株式会社ハッピー
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-199472
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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