Regulation of mast cell function by non-canonical lipid pathway
| Project/Area Number |
16K15122
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo (2017)
Tokyo Metropolitan Institute of Medical Science (2016) |
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Principal Investigator |
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| Research Collaborator |
MURAKAMI Makoto
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マスト細胞 / アレルギー / 脂質代謝 / ホスホリパーゼA2 / 生理活性脂質 / リピドミクス / 分化成熟 / アレルギー応答 / 脂質メディエーター |
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| Outline of Final Research Achievements |
Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze phospholipids to yield fatty acids and lysophospholipids, which serve as precursors for a variety of lipid mediators. It is currently acknowledged that classical lipid mediators such as arachidonic acid metabolites produced by PLA2s modulate mast cell-associated immune response. Moreover, mast cells express a variety of PLA2s or lipid receptors and can alter the release and production of other mediators including histamine, cytokines and chemokines, and thereby homeostatic or pathophysiological responses. Our current studies on newly acknowledged functional aspects of individual PLA2s or lipid receptors in mast cell-mediated immediate-type allergy in relation to non-canonical lipid pathway revealed that (1) the novel regulation of mast cells by a lipid mediator other than classical arachidonate metabolites and (2) the novel PLA2-driven lipid mediator pathway in the regulation of mast cell quality.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury2016
Author(s)
Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J. D., Murakami, M., Hoka, S.,Yokomizo, T.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 34560-34560
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.2016
Author(s)
Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 34690-34690
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.2016
Author(s)
Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M.
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Journal Title
J Biol Chem.
Volume: 291
Issue: 13
Pages: 6895-6911
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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