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Study on the development of lncRNA biomarkers in radiation therapy

Research Project

Project/Area Number 16K20972
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

Miyagawa Ryu  東京大学, 医学部附属病院, 特任助教 (20721939)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsがん / 放射線 / 放射線治療 / バイオマーカー / 非コードRNA / 腫瘍診断 / 長塩基長非コードRNA / 癌 / 核酸 / 細胞・組織
Outline of Final Research Achievements

The purpose of this study is to elucidate the new mechanisms of radiation-responsive non-coding RNA (ncRNA) for the establishment of a new biomarker in radiation therapy. I used X-ray-irradiated cancer-derived cultured cells. First, I identified the expressoion change of some ncRNAs by qPCR. Concurrently, I also identified the localization change of some ncRNAs and some proteins by FISH and IF methods. But I was not able to identify the interaction of those ncRNAs with proteins.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Granule formation of elongator-specific methionine transfer RNA caused by X-ray irradiation in a non-small lung carcinoma cell line (NCI-H1299)2017

    • Author(s)
      Atsuto Katano, *Ryu Miyagawa, Reiko Kobayashi, Hideomi Yamashita, Teepei Morikawa, Akira Sakumi, Yuki Tamari, Masashi Fukayama, Kuni Ohtomo, Keiichi Nakagawa
    • Journal Title

      bioimages

      Volume: 25 Issue: 0 Pages: 1-6

    • DOI

      10.11169/bioimages.25.1

    • NAID

      130006073223

    • ISSN
      0919-2719
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 放射線生物学研究最前線2016

    • Author(s)
      宮川隆
    • Organizer
      平成28年度日本アイソトープ協会・放射線安全取扱部会年次大会
    • Place of Presentation
      鎌倉
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 宮川隆に関するwikipedia

    • URL

      https://ja.wikipedia.org

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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