| Project/Area Number |
17605005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
睡眠学
|
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
MIYAZAKI Soichiro Shiga University of Medical Science, Sleep Medicine, Professor (20200157)
|
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Miyoshi Shiga University of Medical Science, Radiology, Professor (20127038)
KANAI Hirohiko Shiga University of Medical Science, Psychiatry, Associate Professor (30293830)
IMAI Makoto Shiga University of Medical Science, Psychiatry, Assistant Professor (40335170)
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| Project Period (FY) |
2005 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Obstructive sleep apnea / fMRI / Cognitive impairment / Cereberal blood flow / CPAP / Brain volume loss / Frontral cortex / Breath holding |
|---|
| Research Abstract |
Obstructive sleep apnea (OSA) is characterized by diminished upper airway muscle phasic and tonic activation during sleep. Recently, OSA patients show aberrant responses in multiple brain areas, perhaps as a consequence of previously-demonstrated gray matter loss within the frontal cortex, anterior cingulate. In this study, we studied the characteristics of the response of frontal area during breath holding conditions by using functional Magnetic Resonance Imaging (fMRI) and pulse oxymeter in healthy volunteers, and evaluated the impaired cognitive functions in medication-free OSA and control subjects. Average heart rate increased during the breath holding in control subjects and MR signal intensities decreased in frontal lobe. WCST performance exhibited the distinct cognitive impairment in the moderate grade-OSA-patients.
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