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Development and dissemination of the Oxycontin activation program for promoting tailor-made childbirth and child rearing experience

Research Project

Project/Area Number 17H01613
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Lifelong developmental nursing
Research InstitutionSt. Luke's International University

Principal Investigator

HORIUCHI Shigeko  聖路加国際大学, 大学院看護学研究科, 教授 (70157056)

Co-Investigator(Kenkyū-buntansha) 江藤 宏美  長崎大学, 医歯薬学総合研究科(保健学科), 教授 (10213555)
中村 幸代  横浜市立大学, 医学部, 教授 (10439515)
篠原 一之  長崎大学, 医歯薬学総合研究科(医学系), 教授 (30226154)
八重 ゆかり  聖路加国際大学, 大学院看護学研究科, 准教授 (50584447)
片岡 弥恵子  聖路加国際大学, 大学院看護学研究科, 教授 (70297068)
西原 京子  公益財団法人大原記念労働科学研究所, 研究部, 特別研究員 (80172683)
周尾 卓也  北陸大学, 薬学部, 講師 (90399006)
宍戸 恵理  聖路加国際大学, 大学院看護学研究科, 助教 (00881450)
高畑 香織  湘南鎌倉医療大学, 看護学部, 助教 (80818443)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2020: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2018: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2017: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywordsオキシトシン / 無痛分娩 / 自然分娩 / マタニティブルーズ / 妊婦 / 疲労感 / 母親 / ボンディング障害 / 産後うつ / コルチゾール / 分娩 / 看護学
Outline of Final Research Achievements

This study aimed to clarify (a) the association of the delivery mode(i.e., epidural anesthesia or no epidural) with women's changes in longitudinal
salivary oxytocin (OT) levels from late pregnancy to early postpartum, and
(b) the association of these changes with postpartum maternity blues (MB) and fatigue. Results: There were 29 women who delivered with epidural anesthesia and 29 women who did not. A significantly higher mean salivary OT level was observed in the women with epidural anesthesia at 1-2 days after birth than at 36-37 gestational weeks. The mean OT level at 4-5 days postpartum was significantly lower than that at 1-2 days postpartum. The correlation of the MB score with the salivary OT level at 4-5 days postpartum was ρ=-0.33, p = .01.

Academic Significance and Societal Importance of the Research Achievements

オキシトシンは、「愛情ホルモン」「絆ホルモン」といわれ、人との親密性を現す指標として考えられている。妊娠・出産におけるオキシトシンの変化が、分娩様式により異なることが判明し、特に無痛分娩を体験した女性においては、マタニティブルーズや疲労感との関係で、産後にオキシトシンが減少することが判明した。分娩様式を選択する意思決定の際の情報に加えることや、産後ケアの必要性を示している。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (35 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 8 results) Presentation (21 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] Changes in the cortisol and oxytocin levels of first-time pregnant women during interaction with an infant: a randomized controlled trial2021

    • Author(s)
      Sonoda Nozomi、Takahata Kaori、Tarumi Wataru、Shinohara Kazuyuki、Horiuchi Shigeko
    • Journal Title

      BMC Pregnancy and Childbirth

      Volume: 21 Issue: 1 Pages: 162-162

    • DOI

      10.1186/s12884-021-03609-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of epidural anesthesia on postpartum maternity blues and fatigue and its relation to changes in oxytocin2021

    • Author(s)
      Shishido Eri、Shuo Takuya、Shinohara Kazuyuki、Horiuchi Shigeko
    • Journal Title

      Japan Journal of Nursing Science

      Volume: ー Issue: 3

    • DOI

      10.1111/jjns.12406

    • NAID

      210000167728

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of feeding method on a mother's circadian rhythm and on the development of her infant's circadian rest-activity rhythm2020

    • Author(s)
      Kikuchi Sawa、Nishihara Kyoko、Horiuchi Shigeko、Eto Hiromi
    • Journal Title

      Early Human Development

      Volume: 145 Pages: 105046-105046

    • DOI

      10.1016/j.earlhumdev.2020.105046

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a decision aid on the choice of pregnant women whether to have epidural anesthesia or not during labor2020

    • Author(s)
      Shishido Eri、Osaka Wakako、Henna Ayame、Motomura Yuko、Horiuchi Shigeko
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: e0242351-e0242351

    • DOI

      10.1371/journal.pone.0242351

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin levels in low-risk primiparas following breast stimulation for spontaneous onset of labor: A quasi-experimental study.2019

    • Author(s)
      Takahata, K., Horiuchi, S., Tadokoro, Y., Sawano, E., & Shinohara, K.
    • Journal Title

      BMC Pregnancy and Childbirth, 19(1), 351-019-2504-3.

      Volume: 19(1) Issue: 1

    • DOI

      10.1186/s12884-019-2504-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study.2019

    • Author(s)
      Shishido E, Shuo T, Takahata K, Horiuchi S
    • Journal Title

      PloS One, 14(9), e0221821.

      Volume: - Issue: 9 Pages: e0221821-e0221821

    • DOI

      10.1371/journal.pone.0221821

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 無痛分娩の希望とその分娩転帰:自然分娩との比較2018

    • Author(s)
      宍戸恵理,堀内成子
    • Journal Title

      母性衛生

      Volume: 59 Pages: 112-120

    • NAID

      40021561071

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛みおよび疲労についての予測と現実とのギャップ;自然分娩VS無痛分娩2018

    • Author(s)
      宍戸恵理,八重ゆかり,堀内成子
    • Journal Title

      日本助産学会誌

      Volume: 32 Pages: 101-112

    • NAID

      130007549958

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊婦を対象としたふれて・感じる「Mama's Touch プログラム」の実行可能性2018

    • Author(s)
      園田希、小川真世、田所由利子、高畑香織、周尾卓也、堀内成子
    • Journal Title

      日本助産学会誌

      Volume: 32 Pages: 60-72

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠後期女性の個人的背景とクラリセージ精油の香りによるオキシトシン変化との関連2018

    • Author(s)
      田所由利子、堀内成子、周尾卓也、高畑香織、篠原一之
    • Journal Title

      女性健康科学研究会誌

      Volume: 7 Pages: 33-37

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of breast stimulation for spontaneous onset of labor on salivary oxytocin levels in low-risk pregnant women: A feasibility study2018

    • Author(s)
      Takahata Kaori、Horiuchi Shigeko、Tadokoro Yuriko、Shuo Takuya、Sawano Erika、Shinohara Kazuyuki
    • Journal Title

      PLOS One

      Volume: 13 Issue: 2 Pages: e0192757-e0192757

    • DOI

      10.1371/journal.pone.0192757

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in salivary oxytocin after inhalation of clary sage essential oil scent in term-pregnant women: a feasibility pilot study2017

    • Author(s)
      Tadokoro Yuriko、Horiuchi Shigeko、Takahata Kaori、Shuo Takuya、Sawano Erika、Shinohara Kazuyuki
    • Journal Title

      BMC Research Notes

      Volume: 10 Issue: 1 Pages: 3053-3

    • DOI

      10.1186/s13104-017-3053-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 自然分娩・無痛分娩を選択する女性への意思決定エイドの効果、非ランダム化比較試験2021

    • Author(s)
      本村優子、宍戸恵理、大坂和可子、堀内成子
    • Organizer
      第35回日本助産学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 教育講演、オキシトシンの働きから創る助産ケア2021

    • Author(s)
      堀内 成子
    • Organizer
      第35回日本助産学会学術集会 .2021年3月(神戸Web)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 特別講演:絆を育む:オキシトシン活性化研究2020

    • Author(s)
      堀内 成子
    • Organizer
      第76回日本助産師学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Salivary Oxytocin, Maternity Blues, and Postpartum Fatigue2020

    • Author(s)
      Eri Shishido, Shigeko Horiuchi
    • Organizer
      Psotpartum Support International 33ed Annual Conference in New Orleans
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 妊娠末期の乳頭刺激による子宮収縮反応の評価2020

    • Author(s)
      高畑香織, 田所由利子 堀内成子
    • Organizer
      第40回日本看護科学学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 初産婦が乳児とふれ合うことによる乳児へのイメージの変化2020

    • Author(s)
      園田希,高畑香織,堀内成子
    • Organizer
      第34回日本助産学会学術集会 2020年3月 新潟
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自然分娩か無痛分娩かの選択に迷う妊婦を支援する意思決定エイド2020

    • Author(s)
      宍戸恵理,大坂和可子, 本村優子, 有森直子, 堀内成子
    • Organizer
      第34回日本助産学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 質量分析で定量する口腔液含有ペプチドホルモン オキシトシン2019

    • Author(s)
      周尾卓也,宍戸恵理,髙畑香織,堀内成子
    • Organizer
      第39回日本看護科学学会学術集会 2019年12月 石川
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of a Decision Aid Enabling Women to Choose between No Analgesia or Epidural Analgesia during Labour2019

    • Author(s)
      Eri Shishido, Ayame Henna,Wakako Osaka, Naoko Arimori, Shigeko Horiuchi
    • Organizer
      10th International Shared Decision Making Society (ISDM)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自然分娩・無痛分娩を選択する女性への意思決定エイド:国際基準に合わせたエイド開発までの道のり2019

    • Author(s)
      平安名彩恵, 宍戸恵理, 大坂和可子, 堀内成子
    • Organizer
      第60回日本母性衛生学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Changes in Salivary Oxytocin levels in Women from Late Pregnancy to Early Postpartum: Feasibility Study2019

    • Author(s)
      Eri Shishido,Takuya Shuo,Kaori Takahata,Yuriko Tadokoro,Kazuyuki Shinohara,Shigeko Horiuchi
    • Organizer
      23nd East Asian Forum of Nursing Scholars (EAFONS) Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 産後のボンディング障害、マタニティブルーズ、疲労感と唾液オキシトシン値との関連:予備研究2019

    • Author(s)
      宍戸恵理,周尾 卓也,高畑 香織,田所 由利子,八重 ゆかり,堀内 成子
    • Organizer
      第33回日本助産学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 無痛分娩と自然分娩における痛みと疲労の予測と現実とのギャップおよび出産満足度2018

    • Author(s)
      宍戸恵理,八重ゆかり,堀内成子
    • Organizer
      第32回日本助産学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Oxytocin response following breast stimulation in pregnancy:Systematic :A systematic review2018

    • Author(s)
      Kaori Takahata,Eri Shishido,Hiromi Eto,Shigeko Horiuchi
    • Organizer
      4th World Nursing & Healthcare Conference, Rome
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 産後の疲労感における自覚症状:自然分娩と無痛分娩との比較2018

    • Author(s)
      宍戸恵理,堀内成子
    • Organizer
      第59回母性衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ホルモン測定のための異なる唾液貯留方法による唾液量の比較2018

    • Author(s)
      高畑香織,宍戸恵理,田所由利子,堀内成子
    • Organizer
      第59回母性衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The effect of aromatherapy and breast stimulation on oxytocin release2018

    • Author(s)
      Shigeko Horiuchi,Yuriko Tadokoro,Kaori,Takahata,Nozomi Sonoda,Eri Shishido,Hiromi Eto
    • Organizer
      4th World Nursing & Healthcare Conference, Rome
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 妊娠後期女性におけるクラリセージ・ラベンダー精油、ジャスミン精油による足浴前後のオキシトシン・コルチゾールの変化:非無作為化臨床試験2017

    • Author(s)
      田所 由利子, 堀内 成子, 高畑 香織, 岡 美雪, 周尾 卓也, 片岡 弥恵子, 八重 ゆかり
    • Organizer
      第32回日本助産学会学術集会 (横浜)2018年3月
    • Related Report
      2017 Annual Research Report
  • [Presentation] 妊娠末期における陣痛発来のための乳頭刺激プロトコルおよび唾液オキシトシン測定の実行可能性2017

    • Author(s)
      高畑 香織, 堀内 成子, 田所 由利子, 周尾 卓也, 八重ゆかり
    • Organizer
      第32回日本助産学会学術集会 (横浜)2018年3月
    • Related Report
      2017 Annual Research Report
  • [Presentation] ローリスク初産婦における陣痛発来を目的とした乳頭刺激によるオキシトシンへの影響 準ランダム化比較試験2017

    • Author(s)
      高畑 香織, 堀内 成子, 田所 由利子, 丸山 菜穂子, 周尾 卓也
    • Organizer
      第58回日本母性衛生学会学術集会(神戸) 10月6-7日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 無痛分娩の希望とその分娩転帰:自然分娩との比較2017

    • Author(s)
      宍戸恵理,堀内成子
    • Organizer
      第58回日本母性衛生学会学術集会会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 親と子の絆オキシトシン研究会

    • URL

      http://physiologicbirth-midwifery.kenkyuukai.jp/about/index.asp?

    • Related Report
      2020 Annual Research Report
  • [Remarks] 親と子の絆オキシトシン研究会

    • URL

      http://physiologicbirth-midwifery.kenkyuukai.jp/special/?id=22692

    • Related Report
      2019 Annual Research Report 2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-03-24  

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