| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Oxytocin has been shown to have anxiolytic actions and facilitate affiliative behaviors. On the other hand, oxytocin has also been reported to potentiate neuroendocrine stress responses and induce aggressive behavior in some certain conditions. The apparent discrepant data remain to be explained. The objective of the preset study was to determine whether oxytocin systems have heterogeneity and different oxytocin systems meditate different stress responses dependent on situations. The present study suggests that oxytocin receptor-expressing neurons in the insular and/or medial amygdala are involved in affiliative behavior in affiliative conditions, while oxytocin receptor-expressing neurons in the ventromedial hypothalamus and/or periaqueductal gray are involved in active stress coping behaviors in social defeat stress.
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