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Elucidation of global metabolic control mechanisms by microRNA-33a/b and development of specific regulatory strategy using artificial nucleic acid

Research Project

Project/Area Number 17H04177
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

Ono Koh  京都大学, 医学研究科, 准教授 (00359275)

Co-Investigator(Kenkyū-buntansha) 堀江 貴裕  京都大学, 医学研究科, 助教 (20565577)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
KeywordsマイクロRNA / iPS細胞 / 核酸医薬 / 人工核酸 / 代謝 / iPSC
Outline of Final Research Achievements

We revealed that microRNA(miR)-33a/b have essential roles in low HDL-C, atherosclerosis, aortic aneurysm, fibrosis, non-alcoholic steatohepatitis, hypertension, Alzheimer disease, and activation of sympathetic nerve by the use of genetically modified induced pluripotent stem cell and mice. In these experiments, it was shown that miR-33a/b have different target genes in each cell or tissue. Moreover, we developed anti-miR-33a/b oligonucleotides that can selectively suppress the levels of miR-33a or -33b. We applied these oligonucleotides to several disease models and filed a patent for the treatment of aortic aneurysm. We are going to conduct clinical research to identify the clinical application of these oligonucleotides.

Academic Significance and Societal Importance of the Research Achievements

本研究により、microRNA-33a/bが低HDL-C、動脈硬化症、動脈瘤、線維化、NASHを含む慢性炎症、高血圧症、アルツハイマー症、交感神経系の活性化に共通する発症基盤であることが明らかになった。これは我々の作成した遺伝子改変マウスによってのみ明らかにすることができた点であり、学術的意義が高いと考えられる。さらに、miR-33aおよび33bを個別に制御できる架橋型人工核酸を開発し、複数の疾患モデルにおいて治療効果の検討を行っている。すでに大動脈瘤については治療法の特許申請中であり、今後さらに治療可能な疾患が増えることが予想されるため、臨床的・社会的意義も高いと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (55 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (31 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 30 results,  Open Access: 25 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Int'l Joint Research: 7 results,  Invited: 12 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity.2020

    • Author(s)
      Kimura M, Horie T, Baba O, Ide Y, Tsuji S, Ruiz Rodriguez R, Watanabe T, Yamasaki T, Otani C, Xu S, Miyasaka Y, Nakashima Y, Kimura T, Ono K.
    • Journal Title

      EMBO Reports

      Volume: 21 Issue: 4

    • DOI

      10.15252/embr.201948389

    • NAID

      120006936405

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ABLE-MET Investigators. Effects of Metformin on Left Ventricular Size and Function in Hypertensive Patients with Type 2 Diabetes Mellitus: Results of a Randomized, Controlled, Multicenter, Phase IV Trial.2020

    • Author(s)
      Ono K, Wada H, Satoh-Asahara N, Inoue H, Uehara K, Funada J, Ogo A, Horie T, Fujita M, Shimatsu A, Hasegawa K.
    • Journal Title

      Am J Cardiovasc Drugs.

      Volume: 20 Issue: 3 Pages: 283-293

    • DOI

      10.1007/s40256-019-00381-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective Effects of VCP?Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction2019

    • Author(s)
      Ide Yuya, at al.
    • Journal Title

      JACC: Basic to Translational Science

      Volume: 4 Issue: 6 Pages: 701-714

    • DOI

      10.1016/j.jacbts.2019.06.001

    • NAID

      120006734885

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The identification of differential roles of microRNA-33a and -33b during atherosclerosis progression with genetically modified mice.2019

    • Author(s)
      Koyama S, Horie T, Nishino T, Baba O, Sowa N, Miyasaka Y, Kuwabara Y, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Xu S, Yamasaki T, Otani C, Watanabe T, Nakamura T, Hasegawa K, Kimura T, Ono K.
    • Journal Title

      J Am Heart Assoc.

      Volume: 8(13) Issue: 13

    • DOI

      10.1161/jaha.119.012609

    • NAID

      120006818702

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons2019

    • Author(s)
      Nakazeki F、Tsuge I、Horie T、Imamura K、Tsukita K、Hotta A、Baba O、Kuwabara Y、Nishino T、Nakao T、Nishiga M、Nishi H、Nakashima Y、Ide Y、Koyama S、Kimura M、Tsuji S、Naitoh M、Suzuki S、Izumi Y、Kawarai T、Kaji R、Kimura T、Inoue H、Ono K
    • Journal Title

      Clinical Science

      Volume: 133 Issue: 4 Pages: 583-595

    • DOI

      10.1042/cs20180980

    • NAID

      120006937614

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction2018

    • Author(s)
      Hakuno Daihiko、Kimura Masahiro、Ito Shinji、Satoh Junko、Nakashima Yasuhiro、Horie Takahiro、Kuwabara Yasuhide、Nishiga Masataka、Ide Yuya、Baba Osamu、Nishi Hitoo、Nakao Tetsushi、Nishino Tomohiro、Nakazeki Fumiko、Koyama Satoshi、Hanada Ritsuko、Randolph Ruiz R.、Endo Jin、Kimura Takeshi、Ono Koh
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-17

    • DOI

      10.1038/s41598-018-35194-w

    • NAID

      120006645320

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo2018

    • Author(s)
      Nishino T、Horie T、Baba O、Sowa N、Hanada R、Kuwabara Y、Nakao T、Nishiga M、Nishi H、Nakashima Y、Nakazeki F、Ide Y、Koyama S、Kimura M、Nagata M、Yoshida K、Takagi Y、Nakamura T、Hasegawa K、Miyamoto S、Kimura T、Ono K.
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 38 Issue: 10 Pages: 2460-2473

    • DOI

      10.1161/atvbaha.118.311409

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating markers of collagen types I, III, and IV in patients with dilated cardiomyopathy: relationships with myocardial collagen expression2018

    • Author(s)
      Nagao Kazuya、Inada Tsukasa、Tamura Akinori、Kajitani Kenji、Shimamura Kiyotaka、Yukawa Hiroshi、Aida Kenji、Sowa Naoya、Nishiga Masataka、Horie Takahiro、Makita Toshinori、Ono Koh、Tanaka Masaru
    • Journal Title

      ESC Heart Failure

      Volume: 5 Issue: 6 Pages: 1044-1051

    • DOI

      10.1002/ehf2.12360

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo2018

    • Author(s)
      Nakazeki Fumiko、Nishiga Masataka、Horie Takahiro、Nishi Hitoo、Nakashima Yasuhiro、Baba Osamu、Kuwabara Yasuhide、Nishino Tomohiro、Nakao Tetsushi、Ide Yuya、Koyama Satoshi、Kimura Masahiro、Tsuji Shuhei、Sowa Naoya、Yoshida Shigeo、Conway Simon J.、Yanagita Motoko、Kimura Takeshi、Ono Koh
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8553-8553

    • DOI

      10.1038/s41598-018-27009-9

    • NAID

      120006510274

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MicroRNA-33 regulates the population of peripheral inflammatory Ly6Chigh monocytes through dual pathways.2018

    • Author(s)
      Baba O, Horie T, Hakuno D, Nakashima Y, Nishi H, Kuwabara Y, Nakao T, Nishiga M, Nishino T, Ide Y, Nakazeki F, Koyama S, Kimura M, Hanada R, Kawahara M, Kimura T, and Ono K.
    • Journal Title

      Mol Cell Biol.

      Volume: 38 Issue: 14 Pages: 1-17

    • DOI

      10.1128/mcb.00604-17

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long Non-Coding RNAs as Key Regulators of Cardiovascular Diseases2018

    • Author(s)
      Ono K, Kuwabara Y, Horie T, Kimura T.
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 5 Pages: 1231-1236

    • DOI

      10.1253/circj.CJ-18-0169

    • NAID

      130006725985

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Baseline Thrombocytopenia on Bleeding and Mortality after Percutaneous Coronary Intervention2018

    • Author(s)
      Ito Shinya、Watanabe Hirotoshi、Morimoto Takeshi、Yoshikawa Yusuke、Shiomi Hiroki、Shizuta Satoshi、Ono Koh、Yamaji Kyohei、Soga Yoshimitsu、Hyodo Makoto、Shirai Shinichi、Ando Kenji、Horiuchi Hisanori、Kimura Takeshi
    • Journal Title

      Am J Cardiol.

      Volume: 印刷中 Issue: 11 Pages: 1304-1314

    • DOI

      10.1016/j.amjcard.2018.02.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impacto of left ventricular ejection fraction in patients with severe aortic stenosis2018

    • Author(s)
      Taniguchi T, Morimoto T, Shiomi H, Ando K, Kanamori N, Murata K, Kitai T, Kadota K, Izumi C, Nakatsuma K, Sasa T, Watanabe H, Kuwabara Y, Makiyama T, Ono K, Shizuta S, Kato T, Saito N, Minatoya K, Kimura T.
    • Journal Title

      JACC Cardiovascular Interv

      Volume: 11 Issue: 2 Pages: 145-157

    • DOI

      10.1016/j.jcin.2017.08.036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia.2017

    • Author(s)
      Tsumaru S, Masumoto H, Minakata K, Izuhara M, Yamazaki K, Ikeda T, Ono K, Sakata R, Minatoya K.
    • Journal Title

      J Vasc Surg.

      Volume: 印刷中 Issue: 4 Pages: 1209-1215

    • DOI

      10.1016/j.jvs.2017.08.097

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preclinical evaluation of a paclitaxel-incorporated nanoparticle-coated balloon in rabbit and porcine models.2017

    • Author(s)
      Yamamoto E, Watanabe S, Bao B, Watanabe H, Nakatsuma K, Izuhara M, Ono K, Nakazawa G, Kimura T, Saito N.
    • Journal Title

      Cardiovasc Revasc Med.

      Volume: 印刷中 Issue: 4 Pages: 433-437

    • DOI

      10.1016/j.carrev.2017.10.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators. Single-session Versus Staged Procedures for Elective Multi-vessel Percutaneous Coronary Intervention.2017

    • Author(s)
      Toyota T, Morimoto T, Shiomi H, Yamaji K, Ando K, Ono K, Shizuta S, Saito N, Kato T, Kaji S, Furukawa Y, Nakagawa Y, Kadota K, Horie M, Kimura T,
    • Journal Title

      Heart.

      Volume: Nov 16. Issue: 11 Pages: 936-944

    • DOI

      10.1136/heartjnl-2017-312117

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Transient or Persistent Contrast-Induced Nephropathy on Long-Term Mortality after Elective Percutaneous Coronary Intervention.2017

    • Author(s)
      Abe M, Morimoto T, Nakagawa Y, Furukawa Y, Ono K, Kato T, Kadota K, Ando K, Ishii M, Masunaga N, Akao M, Kimura T.
    • Journal Title

      Am J Cardiol.

      Volume: Dec 15;120(12): Issue: 12 Pages: 2146-2153

    • DOI

      10.1016/j.amjcard.2017.08.036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Very long-term clinical outcomes after radiofrequency catheter ablation for atrial fibrillation: A large single-center experience.2017

    • Author(s)
      Kawaji T, Shizuta S, Morimoto T, Aizawa T, Yamagami S, Yoshizawa T, Ota C, Onishi N, Sasaki Y, Yahata M, Nakai K, Hayano M, Nakao T, Hanazawa K, Goto K, Doi T, Ono K, Kimura T.
    • Journal Title

      Int J Cardiol.

      Volume: 249 Pages: 204-213

    • DOI

      10.1016/j.ijcard.2017.09.023

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways.2017

    • Author(s)
      Nakao T, Horie T, Baba O, Nishiga M, Nishino T, Izuhara M, Kuwabara Y, Nishi H, Usami S, Nakazeki F, Ide Y, Koyama S, Kimura M, Sowa N, Ohno S, Aoki H, Hasegawa K, Sakamoto K, Minatoya K, Kimura T, Ono K.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 37 Issue: 11 Pages: 2161-2170

    • DOI

      10.1161/atvbaha.117.309768

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imbalanced expression of polycistronic miRNA in acute myeloid leukemia.2017

    • Author(s)
      Kotaki R, Higuchi H, Ogiya D, Katahira Y, Kurosaki N, Yukihira N, Ogata J, Yamamoto H, Mohamad Alba S, Azhim A, Kitajima T, Inoue S, Morishita K, Ono K, Koyama-Nasu R, Kotani A.
    • Journal Title

      Int J Hematol.

      Volume: 106 Issue: 6 Pages: 811-819

    • DOI

      10.1007/s12185-017-2314-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation2017

    • Author(s)
      Komiyama Maki、Wada Hiromichi、Ono Koh、Yamakage Hajime、Satoh-Asahara Noriko、Shimada Sayaka、Akao Masaharu、Morimoto Tatsuya、Shimatsu Akira、Takahashi Yuko、Sawamura Tatsuya、Hasegawa Koji
    • Journal Title

      Heart and Vessels

      Volume: 33 Issue: 1 Pages: 9-16

    • DOI

      10.1007/s00380-017-1026-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome2017

    • Author(s)
      Chen Po-Min、Ohno Mikiko、Hiwasa Takaki、Nishi Kiyoto、Saijo Sayaka、Sakamoto Jiro、Morita Yusuke、Matsuda Shintaro、Watanabe Shin、Kuwabara Yasuhide、Ono Koh、Imai Masao、Inoue Katsumi、Murai Tatsuya、Inada Tsukasa、Tanaka Masaru、Kita Toru、Kimura Takeshi、Nishi Eiichiro
    • Journal Title

      International Journal of Cardiology

      Volume: 243 Pages: 1-8

    • DOI

      10.1016/j.ijcard.2017.04.047

    • NAID

      130007900462

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transradial versus transfemoral approach in patients undergoing primary percutaneous coronary intervention for ST-elevation acute myocardial infarction: insight from the CREDO-Kyoto AMI registry.2017

    • Author(s)
      Yamashita Y, Shiomi H, Morimoto T, Yaku H, Kaji S, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Abe M, Akao M, Nagao K, Shizuta S, Ono K, Kimura T
    • Journal Title

      Heart Vessels.

      Volume: 32 Issue: 12 Pages: 1936-1944

    • DOI

      10.1007/s00380-017-1021-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymptomatic Lower Extremity Deep Vein Thrombosis ― Clinical Characteristics, Management Strategies, and Long-Term Outcomes ―2017

    • Author(s)
      Yamashita Y, Shiomi H, Morimoto T, Yoneda T, Yamada C, Makiyama T, Kato T, Saito N, Shizuta S, Ono K, Kimura T.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 12 Pages: 1936-1944

    • DOI

      10.1253/circj.CJ-17-0445

    • NAID

      130006219233

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of <i>SCN5A</i>-D1275N-Related Cardiac Sodium Channelopathy2017

    • Author(s)
      Hayano M, Makiyama T
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 12 Pages: 1783-1791

    • DOI

      10.1253/circj.CJ-17-0064

    • NAID

      130006219109

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic changes of serum microRNA-122-5p through therapeutic courses indicates amelioration of acute liver injury accompanied by acute cardiac decompensation.2017

    • Author(s)
      Satoshi Koyama, Takashi Kuragaichi, Yukihito Sato, Yasuhide Kuwabara, Shunsuke Usami, Takahiro Horie, Osamu Baba, Daihiko Hakuno, Yasuhiro Nakashima, Tomohiro Nishino, Masataka Nishiga, Tetsushi Nakao, Hidenori Arai, Takeshi Kimura, Koh Ono
    • Journal Title

      ESC Heart Failure

      Volume: 4 Issue: 2 Pages: 112-121

    • DOI

      10.1002/ehf2.12123

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease2017

    • Author(s)
      Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada K. H, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 4 Pages: e0175649-e0175649

    • DOI

      10.1371/journal.pone.0175649

    • NAID

      120006534994

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Incidence and Prognostic Impact of Heart Failure Hospitalization During Follow-up after Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction.2017

    • Author(s)
      Taniguchi T, Horie M, et al.
    • Journal Title

      American Journal of Cardiology

      Volume: 印刷中 Issue: 11 Pages: 1729-1739

    • DOI

      10.1016/j.amjcard.2017.03.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model.2017

    • Author(s)
      Izuhara M, Kuwabara Y, Saito N, Yamamoto E, Hakuno D, Nakashima Y, Horie T, Baba O, Nishiga M, Nakao T, Nishino T, Nakazeki F, Ide Y, Kimura M, Kimura T, Ono K.
    • Journal Title

      PLoS One

      Volume: 12(3) Issue: 3 Pages: e0172798-e0172798

    • DOI

      10.1371/journal.pone.0172798

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac and Noncardiac Causes of Long-Term Mortality in ST-Segment-Elevation Acute Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention.2017

    • Author(s)
      Yamashita Y, Shiomi H, Morimoto T, Yaku H, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Abe M, Nagao K, Shizuta S, Ono K, Kimura T; CREDO-Kyoto AMI Registry Investigators.
    • Journal Title

      Circ Cardiovasc Qual Outcomes.

      Volume: 10 Issue: 1

    • DOI

      10.1161/circoutcomes.116.002790

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.2016

    • Author(s)
      Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K.
    • Journal Title

      Circ Res.

      Volume: - Issue: 5 Pages: 835-847

    • DOI

      10.1161/circresaha.116.309528

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] The identification of differential roles of microRNA-33a and -33b furing atherosclerosis progression with genetically modified mice.2019

    • Author(s)
      Ono K.
    • Organizer
      APASVD 2019 Congress.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MicroRNA in cardiovascular biology and disease.2019

    • Author(s)
      Ono K.
    • Organizer
      2019 XXIII ISHR WORLD CONGRESS
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アテローム性動脈硬化形成におけるmicroRNA-33aおよび-33bが与える影響の違い2019

    • Author(s)
      尾野 亘
    • Organizer
      日本炎症・再生医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 非コードRNAの心不全における役割2019

    • Author(s)
      尾野 亘
    • Organizer
      第55回日本小児循環器学会総会・学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 長鎖非コードRNAの心不全・拡張型心筋症における役割2019

    • Author(s)
      尾野 亘
    • Organizer
      第23回日本心不全学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 1.SREBF1/MicroRNA-33b axis exhibits potent effect on unstable atherosclerotic plaque formation in vivo.2018

    • Author(s)
      Koh Ono
    • Organizer
      XVIIIth International Symposium on Atherosclerosis.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] SREBF1/MicroRNA-33b axis は不安定プラークの形成に重要である2018

    • Author(s)
      尾野 亘
    • Organizer
      第50回日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Functions of microRNA-33a/b on inflammation and atherosclerosis2018

    • Author(s)
      Koh Ono
    • Organizer
      China-Japan International Conference on Atherosclerosis 2018.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マイクロRNAと心血管疾患、代謝性疾患2018

    • Author(s)
      尾野 亘
    • Organizer
      第66回日本心臓病学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MicroRNA-33の欠損は複数の抗炎症経路を介して大動脈瘤の形成を抑制する2018

    • Author(s)
      尾野 亘
    • Organizer
      第59回日本脈管学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A Novel Long Intergenic Noncoding RNA, Lionheart, Protects the Heart from Pressure Overload2018

    • Author(s)
      尾野 亘
    • Organizer
      第83回 日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Novel Long Intergenic Noncoding RNA, Lionheart, Guards the Heart from Pressure Overload2018

    • Author(s)
      Kuwabara Y, Horie T, Baba O, Nishiga M, Nakao M, Nishino T, Nakazeki F, Koyama S, Kimura T, Ono K.
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice2018

    • Author(s)
      Nishino T, Horie T, Baba O, Kuwabara Y, Hakuno D, Nakashima Y, Nakao T, Nishiga M, Kimura T, Ono K.
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Roles of microRNAs in cardiovascular diseases2017

    • Author(s)
      Koh Ono
    • Organizer
      2nd International Symposium for Noncoding RNA Neo-taxonomy In conjunction with Tokyo RNA Club 23rd meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice.2017

    • Author(s)
      Koh Ono
    • Organizer
      43rd Naito Conference Noncoding RNA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice.2017

    • Author(s)
      Nishino T, Horie T, Kuwabara Y, Nakao T, Nishiga M, Ide Y, Nakazeki F, Koyama S, Kimura M, Kimura T, Ono K
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 循環器疾患 最新の治療2020-20212020

    • Author(s)
      尾野 亘
    • Publisher
      南江堂
    • Related Report
      2019 Annual Research Report
  • [Book] 循環器疾患の最新医療2019

    • Author(s)
      尾野 亘
    • Publisher
      先端医療技術研究所
    • Related Report
      2019 Annual Research Report
  • [Book] 心不全(第2版)2019

    • Author(s)
      尾野 亘
    • Publisher
      日本臨床社
    • Related Report
      2019 Annual Research Report
  • [Remarks] 京都大学循環器内科 分子循環器グループ

    • URL

      http://kyoto-u-cardio.jp/kisokenkyu/metabolic/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 心血管疾患分子機構解明グループ

    • URL

      http://kyoto-u-cardio.jp/kisokenkyu/metabolic/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] miR-33b阻害物質による動脈瘤の予防または治療2020

    • Inventor(s)
      尾野 亘、堀江貴裕、小山智史、山崎智弘
    • Industrial Property Rights Holder
      尾野 亘、堀江貴裕、小山智史、山崎智弘
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-034619
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 遺伝性痙性対麻痺(Hereditary Spastic Paraplegia; HSP)SPG4 に対するmicroRNA-33a抑制療法2018

    • Inventor(s)
      尾野 亘、井上治久、今村恵子、堀江貴裕、中関典子
    • Industrial Property Rights Holder
      尾野 亘、井上治久、今村恵子、堀江貴裕、中関典子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-119251
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] miR-33bノックインマウスによる非アルコール性脂肪肝炎モデル2018

    • Inventor(s)
      尾野 亘、堀江貴裕、西野共達
    • Industrial Property Rights Holder
      尾野 亘、堀江貴裕、西野共達
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas

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Published: 2017-04-28   Modified: 2025-01-30  

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