| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
We investigated the expression of sensory receptor channel molecule TRPA1 in atopic dermatitis model mice using immunohistochemistry. A positive reaction for TRPA1 was detected in the sensory nerves of the auricular hair follicles. Subsequent topical administration of several therapeutic agents for atopic dermatitis or TRPA1 inhibitors showed that steroids and antihistamines were effective, but TRPA1 inhibitors also showed some improvement in inflammation. In the TRPA1 inhibitor-administered cases, a positive TRPA1 reaction could not be detected. Furthermore, we compared the administration of TRPA1 inhibitor ointment or ointment base. The cure rate for atopic dermatitis was higher in the TRPA1 inhibitor ointment group than in the ointment base group. These results suggest that the TRPA1 inhibitor may be effective for chronic dermatitis in atopic dermatitis model mice.
|
