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Investigation of amino acids contribution to schizophrenia etiology using structural equation modeling.

Research Project

Project/Area Number 17K10281
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionShiga University of Medical Science (2018-2019)
Dokkyo Medical University (2017)

Principal Investigator

Ozeki Yuji  滋賀医科大学, 医学部, 教授 (90303768)

Co-Investigator(Kenkyū-buntansha) 藤井 久彌子  滋賀医科大学, 医学部, 准教授 (70314151)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords統合失調症 / アミノ酸 / D-セリン / L-セリン / グルタミン酸 / グルタミン / アラニン / BACS-J / グリシン / BACS / 構造方程式モデリング法 / 構造方程式モデリング
Outline of Final Research Achievements

The serum concentration of 18 kinds of amino acids was measured in 127 patients with schizophrenia (SZ) and 64 healthy controls (HC). L-Alanine concentration was significantly decreased in SZ by logistic regression analysis. Furthermore, in SZ, the correlation between amino acid concentration and clinical symptoms by PANSS and cognitive function by BACS-J was investigated. L-serine concentration correlated with positive symptoms. glutamic acid and D-serine concentration correlate with attention, with a positive and negative manner respectively. The rare mutation was found in one of the L-serine synthesis enzymes. The function of the mutations was investigated in HEK293 cells. One mutation modified amino acid concentration which is similar to the patient who has the mutation. This project indicates the possibility that amino acid could affect symptoms of schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

統合失調症は0.8%ほどの人がかかる疾患で、幻覚妄想などの症状とともに、考える力が下がるなど一種の後遺症があります。また、治療を受けていても症状を繰り返す場合も少なくなりません。投薬などの治療は改善されてきていますが、後遺症や再発の恐れは完全には解決されていません。そのため、どうして病気になるのかといった研究を通して、新たな治療法を見つける必要があります。今回の研究ではこれまでに提出されていたアミノ酸と統合失調症との関係をより詳しく調べました。その結果D-セリンなど一部のアミノ酸が症状と関係している可能性が認められました。こうした成果は今後の疾患克服に有用な情報を提供すると考えられます。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Slower Titration of Lamotrigine Reduces the Risk of Rash.2020

    • Author(s)
      Kumiko Fujii, Hiroaki Okayasu, Takahiro Shinozaki, Kazutaka Shimoda, Yuji Ozeki
    • Journal Title

      Psychiatry and clinical neurosciences

      Volume: 74 Issue: 4 Pages: 282-283

    • DOI

      10.1111/pcn.12987

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural determination of lysosphingomyelin-509 and discovery of novel class lipids from patients with niemann–pick disease type C2019

    • Author(s)
      Masamitsu Maekawa, Isamu Jinnoh, Yotaro Matsumoto, Aya Narita, Ryuichi Mashima, Hidenori Takahashi, Anna Iwahori, Daisuke Saigusa, Kumiko Fujii, Ai Abe, Katsumi Higaki, Shosei Yamauchi, Yuji Ozeki, Peter T Clayton, Hiroaki Yamaguchi, Nariyasu Mano, et al.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 20 Pages: 5018-5018

    • DOI

      10.3390/ijms20205018

    • URL

      https://localhost/en/publications/0001eeaa-b3d0-44fb-bd40-42657503d092

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine2019

    • Author(s)
      Shinozaki Masataka、Pierce Jason、Hayashi Yuki、Watanabe Takashi、Sasaki Taro、Komahashi-Sasaki Hazuki、Akiyama Kazufumi、Kato Kazuko、Inoue Yoshimasa、Tsuchimine Shoko、Yasui-Furukori Norio、Ozeki Yuji、Shimoda Kazutaka
    • Journal Title

      Pharmacopsychiatry

      Volume: 52 Issue: 05 Pages: 237-244

    • DOI

      10.1055/a-0918-6408

    • NAID

      130007811500

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Genetic Variants at 22q11.2 Chromosomal Region with Cognitive Performance in Japanese Patients with Schizophrenia.2019

    • Author(s)
      Akiyama K, Saito A, Saito S, Ozeki Y, Watanabe T, Fujii K, Shimoda K
    • Journal Title

      Schizophrenia Research: Cognition

      Volume: 印刷中 Pages: 100134-100134

    • DOI

      10.1016/j.scog.2019.100134

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 血漿中アミノ酸濃度と認知機能の関係:構造方程式モデリングを用いた評価2019

    • Author(s)
      尾関祐二、関根正恵、藤井久彌子、岡安寛明、秋山一文、本間浩、下田和孝
    • Organizer
      第115回日本精神神経学会総会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 統合失調症患者における神経発達症合併の臨床経過への影響の評価2019

    • Author(s)
      尾関祐二 藤井久彌子 Katja Koelkebeck 下田和孝
    • Organizer
      第115回日本精神神経学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The relationship between peripheral amino acids alteration and symptoms of schizophrenia including neurocognitive dysfunction.2018

    • Author(s)
      Yuji Ozeki
    • Organizer
      WFBS 2018 KOBE
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症患者におけるL-セリン合成酵素の遺伝情報と臨床症状との関係の検索2017

    • Author(s)
      尾関祐二、関根正恵、藤井久彌子、髙野有美子、岡安寛明、篠崎隆央、渡邊崇、青木顕子、青木秀明、森玄房、秋山一文、本間浩、下田和孝
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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