| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
Abnormal tau protein aggregation along with cerebral atrophy is important pathological characteristics in the brains of Alzheimer's disease and frontotemporal dementia. In this study, we focused on the neurotoxicity of tau oligomers and their propagation. Extracellular tau oligomers caused neurotoxicity in neurons derived from FTLD-patient iPS cells, and the results indicated that the toxicity was propagated in a neural activity-dependent manner. Furthermore, we identified compounds that inhibited tau oligomer accumulation and neuronal cell death. We also reported that an intranasal tau vaccine was effective in FTLD mouse model. We explored potential therapeutic approaches based on the neurotoxic mechanisms of tau oligomers and their propagation.
|
