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Computational fluid dynamic study of various different individual coronary artery bypass grafting model

Research Project

Project/Area Number 17K10723
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionChiba University

Principal Investigator

Matsuura Kaoru  千葉大学, 医学部附属病院, 助教 (50436375)

Co-Investigator(Kenkyū-buntansha) 松宮 護郎  千葉大学, 大学院医学研究院, 教授 (20314312)
上田 秀樹  千葉大学, 医学部附属病院, 講師 (50738987)
黄野 皓木  千葉大学, 医学部附属病院, 助教 (40375803)
渡邉 倫子  千葉大学, 医学部附属病院, 助教 (20766274)
劉 浩  千葉大学, 大学院工学研究院, 教授 (40303698)
田村 友作  千葉大学, 医学部附属病院, 助教 (60738988)
焼田 康紀  千葉大学, 医学部附属病院, 助教 (40790671)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心臓血管外科 / 冠動脈外科 / 数値流体力学的研究 / 解析モデル / 数値流体力学 / 数値流体力学研究
Outline of Final Research Achievements

e conducted the computational fluid dynamic study of the various individual models. In the native occlusion model, diamond sequential anastomosis would be an effective option for sequential bypass because of the better flow to the bypass outlet than with parallel anastomosis. Flow competition should be kept in mind while using diamond anastomosis for moderately stenotic vessels because of worsened flow to the native outlet.
In the native coronary stenosis and end-side anastomosis model, an anastomosis length of 8 mm was the ideal length with less flow complexity, low OSI, and less energy loss and high energy efficiency in the native 90% stenosis model.
In the multiple coronary artery bypass model, It was ideal to bypass the less severe stenosis vessel first with a parallel anastomosis method when employing multiple sequential bypass grafting. This improved hemodynamic stability and energy efficiency, according to a computational fluid dynamics model.

Academic Significance and Societal Importance of the Research Achievements

複雑な冠動脈病変には冠動脈バイパスがカテーテル治療より優れているという研究結果が得られてきた一方で冠動脈バイパスのComputational fluid dynamics(CFD)研究はシンプルな吻合形態についての研究にとどまり、複雑なバイパス吻合形態のどれが血行動態力学的に最適なのかという検討はいまだに乏しいのが現状であった。今回の我々の研究により、理想的な血行動態を示す冠動脈バイパスの吻合形態や、グラフトデザインを示すことができ、冠動脈バイパス術の適応の再確認につながったと考える。また今回の結果により患者説明、医学教育に寄与するだけでなく、病態把握へ重要な役割を果たすことができると考える。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report

Research Products

(14 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Computational fluid dynamic study of multiple sequential coronary artery bypass anastomoses in a native coronary stenosis model.2020

    • Author(s)
      Matsuura K, Jin WW, Liu H, Matsumiya G.
    • Journal Title

      Coronary Artery Disease

      Volume: - Pages: 458-463

    • DOI

      10.1097/mca.0000000000000864

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational fluid dynamic study of different incision length of coronary artery bypass grafting in a native coronary stenosis model2019

    • Author(s)
      Matsuura Kaoru、Jin Wei Wei、Liu Hao、Matsumiya Goro
    • Journal Title

      Journal of Thoracic Disease

      Volume: 11(2) Pages: 393-399

    • DOI

      10.21037/jtd.2019.01.35

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational fluid dynamics study of the end-side and sequential coronary artery bypass anastomoses in a native coronary occlusion model.2017

    • Author(s)
      Matsuura Kaoru、Jin Wei Wei、Liu Hao、Matsumiya Goro
    • Journal Title

      Interact Cardiovasc Thorac Surg.

      Volume: 26(4) Pages: 583-589

    • DOI

      10.1093/icvts/ivx376

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Computational fluid dynamic study of end-side anastomosis after coronary artery bypass grafting2020

    • Author(s)
      Yasunori Yakita, Kaoru Matsuura
    • Organizer
      STS 56th Annual meeting.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] CABG術後、心電図同期冠動脈3DCTを用いた血流モデルの解析:SVGについて2019

    • Author(s)
      焼田康紀,松浦馨,上田秀樹,黄野皓木,渡邉倫子,乾友彦,平岡大輔,諫田朋佳,藤井政彦,池内博紀,坂田朋基,西織浩信,松宮護郎
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] CABG術後、心電図同期冠動脈3DCTを用いた血流解析モデルの作成:end-side吻合について2019

    • Author(s)
      焼田康紀、松浦馨、上田秀樹、黄野皓木、榎本吉倫、渡邉倫子、平岡大輔、乾友彦、若林豊、諫田朋佳、藤井政彦、伊藤駿太郎、松宮護郎
    • Organizer
      第49回日本心臓血管外科学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] End-side吻合CABG VFDモデルでのnative閉塞モデルと狭窄モデルに比較2018

    • Author(s)
      松浦馨、焼田康紀、上田秀樹、黄野皓木、榎本吉倫、渡邉倫子、乾友彦、平岡大輔、若林豊、諫田朋佳、藤井政彦、伊藤駿太郎、松宮護郎
    • Organizer
      第23回日本冠動脈外科学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] CFD解析を用いたMultiple sequential CABGモデルの血流動態の検討2018

    • Author(s)
      松浦馨、上田秀樹、黄野皓木、田村友作、渡邉倫子、乾友彦、稲毛雄一、焼田康紀、若林豊、柴田裕輔、山田隆煕、山本浩亮、松宮護郎
    • Organizer
      第71回日本胸部外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Computational fluid dynamic study of sequential coronary artery bypass grafting in the native coronay occlusion model: Distribution of flow and energy efficiency2018

    • Author(s)
      Kaoru Matsuura
    • Organizer
      2018 SJTU Workshop (Joint Seminar with JSPS Core-to-Core Program) on Medical Imaging and Computational Modeling in Cardiovascular and Pulmonary Diseases
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Native coronary 狭窄end-side吻合CABGモデルでのCFD解析-吻合長の影響2018

    • Author(s)
      松浦馨、上田秀樹、黄野皓木、田村友作、渡邉倫子、乾友彦、稲毛雄一、焼田康紀、松宮護郎
    • Organizer
      第48回日本心臓血管外科学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 心電図同期冠動脈3DCTを用いた血流解析モデルの作成: ITA-LAD吻合について2018

    • Author(s)
      焼田康紀、松浦馨、上田秀樹、黄野皓木、田村友作、渡邉倫子、乾友彦、稲毛雄一、若林豊、山田隆煕、山本浩亮、松宮護郎
    • Organizer
      第48回日本心臓血管外科学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Computational fluid dynamic model of sequential coronary artery bypass grafting in the native coronary occlusion model2018

    • Author(s)
      Kaoru Matsuura, Weiwei Jin, Hao Liu, Goro Matsumiya.
    • Organizer
      日本医工学治療学会 第34回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Computational fluid dynamic study of sequential coronary artery bypass grafting in the native coronary occlusion model :Distribution of flow and energy efficiency.2017

    • Author(s)
      Kaoru Matsuura MD, PhD, Wewei Jin, Hao Liu, Goro Matsumiya.
    • Organizer
      2017 31th European Association of CardioThoracic Surgery Annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Native完全閉塞CABGモデルにおける各吻合形態の血流動態、特にflowとenergy efficiencyの分布について2017

    • Author(s)
      松浦馨、上田秀樹、黄野皓木、田村友作、渡邉倫子、乾友彦、稲毛雄一、焼田康紀、松宮護郎
    • Organizer
      第70回日本胸部外科学会定期学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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